The Th17/Treg Cytokine Imbalance in Chronic Obstructive Pulmonary Disease Exacerbation in an Animal Model of Cigarette Smoke Exposure and Lipopolysaccharide Challenge Association

We proposed an experimental model to verify the Th17/Treg cytokine imbalance in COPD exacerbation. Forty C57BL/6 mice were exposed to room air or cigarette smoke (CS) (12 ± 1 cigarettes, twice a day, 30 min/exposure and 5 days/week) and received saline (50 µl) or lipopolysaccharide (LPS) (1 mg/kg in...

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Detalles Bibliográficos
Autores principales: Cervilha, Daniela A. B., Ito, Juliana T., Lourenço, Juliana D., Olivo, Clarice R., Saraiva-Romanholo, Beatriz M., Volpini, Rildo A., Oliveira-Junior, Manoel C., Mauad, Thais, Martins, Milton A., Tibério, Iolanda F. L. C., Vieira, Rodolfo P., Lopes, Fernanda D. T. Q. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374436/
https://www.ncbi.nlm.nih.gov/pubmed/30760822
http://dx.doi.org/10.1038/s41598-019-38600-z

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