Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Different thresholds of Wnt signalling are thought to drive stem cell maintenance, regeneration, differentiation and cancer. However, the principle that oncogenic Wnt signalling could be specifically targeted remains controversial. Here we examine the requirement of BCL9/9l, constituents of the Wnt-...

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Detalles Bibliográficos
Autores principales: Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374445/
https://www.ncbi.nlm.nih.gov/pubmed/30760720
http://dx.doi.org/10.1038/s41467-019-08586-3

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