Identification of Recessive Lethal Alleles in the Diploid Genome of a Candida albicans Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact

The heterozygous diploid genome of Candida albicans is highly plastic, with frequent loss of heterozygosity (LOH) events. In the SC5314 laboratory strain, while LOH events are ubiquitous, a chromosome homozygosis bias is observed for certain chromosomes, whereby only one of the two homologs can occu...

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Detalles Bibliográficos
Autores principales: Marton, Timea, Feri, Adeline, Commere, Pierre-Henri, Maufrais, Corinne, d’Enfert, Christophe, Legrand, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374597/
https://www.ncbi.nlm.nih.gov/pubmed/30760617
http://dx.doi.org/10.1128/mSphere.00709-18

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