CRISPR-Mediated Editing of the B Cell Receptor in Primary Human B Cells

Vaccination approaches have generally focused on the antigen rather than the resultant antibodies generated, which differ greatly in quality and function between individuals. The ability to replace the variable regions of the native B cell receptor (BCR) heavy and light chain loci with defined recom...

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Detalles Bibliográficos
Autores principales: Greiner, Vera, Bou Puerto, Regina, Liu, Suying, Herbel, Christoph, Carmona, Ellese M., Goldberg, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374785/
https://www.ncbi.nlm.nih.gov/pubmed/30769282
http://dx.doi.org/10.1016/j.isci.2019.01.032

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