Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1)

We report a case of ceftriaxone-induced immune hemolytic anemia in a 10-year-old with chronic active Epstein–Barr virus disease and hemophagocytic lymphohistiocytosis. After chemotherapy, she became febrile and received ceftriaxone. She rapidly developed respiratory failure and anemia. Her direct an...

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Autores principales: Cunnion, Kenji M., Feagin, Lisa M., Chicella, Michael F., Kaszowski, Cortney L., Hair, Pamela S., Price, Jessica, Owen, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374879/
https://www.ncbi.nlm.nih.gov/pubmed/30838143
http://dx.doi.org/10.1155/2019/4105653
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author Cunnion, Kenji M.
Feagin, Lisa M.
Chicella, Michael F.
Kaszowski, Cortney L.
Hair, Pamela S.
Price, Jessica
Owen, William C.
author_facet Cunnion, Kenji M.
Feagin, Lisa M.
Chicella, Michael F.
Kaszowski, Cortney L.
Hair, Pamela S.
Price, Jessica
Owen, William C.
author_sort Cunnion, Kenji M.
collection PubMed
description We report a case of ceftriaxone-induced immune hemolytic anemia in a 10-year-old with chronic active Epstein–Barr virus disease and hemophagocytic lymphohistiocytosis. After chemotherapy, she became febrile and received ceftriaxone. She rapidly developed respiratory failure and anemia. Her direct antiglobulin test was positive for IgG and C3. To confirm this was ceftriaxone-induced complement-mediated hemolysis, we adapted the complement hemolysis using human erythrocytes (CHUHE) assay by adding exogenous ceftriaxone to the patient's serum which enhanced lysis of her erythrocytes. We confirmed that ceftriaxone initiated a classical complement pathway-mediated hemolysis by in vitro reversal with peptide inhibitor of complement C1 (PIC1).
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spelling pubmed-63748792019-03-05 Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1) Cunnion, Kenji M. Feagin, Lisa M. Chicella, Michael F. Kaszowski, Cortney L. Hair, Pamela S. Price, Jessica Owen, William C. Case Rep Hematol Case Report We report a case of ceftriaxone-induced immune hemolytic anemia in a 10-year-old with chronic active Epstein–Barr virus disease and hemophagocytic lymphohistiocytosis. After chemotherapy, she became febrile and received ceftriaxone. She rapidly developed respiratory failure and anemia. Her direct antiglobulin test was positive for IgG and C3. To confirm this was ceftriaxone-induced complement-mediated hemolysis, we adapted the complement hemolysis using human erythrocytes (CHUHE) assay by adding exogenous ceftriaxone to the patient's serum which enhanced lysis of her erythrocytes. We confirmed that ceftriaxone initiated a classical complement pathway-mediated hemolysis by in vitro reversal with peptide inhibitor of complement C1 (PIC1). Hindawi 2019-01-30 /pmc/articles/PMC6374879/ /pubmed/30838143 http://dx.doi.org/10.1155/2019/4105653 Text en Copyright © 2019 Kenji M. Cunnion et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Cunnion, Kenji M.
Feagin, Lisa M.
Chicella, Michael F.
Kaszowski, Cortney L.
Hair, Pamela S.
Price, Jessica
Owen, William C.
Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1)
title Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1)
title_full Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1)
title_fullStr Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1)
title_full_unstemmed Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1)
title_short Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1)
title_sort ceftriaxone-induced immune hemolytic anemia: in vitro reversal with peptide inhibitor of complement c1 (pic1)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374879/
https://www.ncbi.nlm.nih.gov/pubmed/30838143
http://dx.doi.org/10.1155/2019/4105653
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