Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents

Alzheimer's disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer's disease. Various substituted 3-arylcoumarin derivatives were synthesised, and their in vitro activ...

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Detalles Bibliográficos
Autores principales: Yang, Jie, Zhang, Pingping, Hu, Yuheng, Liu, Teng, Sun, Jie, Wang, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374920/
https://www.ncbi.nlm.nih.gov/pubmed/30746966
http://dx.doi.org/10.1080/14756366.2019.1574297
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author Yang, Jie
Zhang, Pingping
Hu, Yuheng
Liu, Teng
Sun, Jie
Wang, Xiaojing
author_facet Yang, Jie
Zhang, Pingping
Hu, Yuheng
Liu, Teng
Sun, Jie
Wang, Xiaojing
author_sort Yang, Jie
collection PubMed
description Alzheimer's disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer's disease. Various substituted 3-arylcoumarin derivatives were synthesised, and their in vitro activity, including cholinesterase inhibitory activity, monoamine oxidase inhibitory activity, and antioxidant activity were investigated. Most of the compounds exhibited high activity; therefore 3-arylcoumarin compounds have the potential as drug candidates for the treatment of Alzheimer's disease.
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spelling pubmed-63749202019-02-20 Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents Yang, Jie Zhang, Pingping Hu, Yuheng Liu, Teng Sun, Jie Wang, Xiaojing J Enzyme Inhib Med Chem Research Paper Alzheimer's disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer's disease. Various substituted 3-arylcoumarin derivatives were synthesised, and their in vitro activity, including cholinesterase inhibitory activity, monoamine oxidase inhibitory activity, and antioxidant activity were investigated. Most of the compounds exhibited high activity; therefore 3-arylcoumarin compounds have the potential as drug candidates for the treatment of Alzheimer's disease. Taylor & Francis 2019-02-12 /pmc/articles/PMC6374920/ /pubmed/30746966 http://dx.doi.org/10.1080/14756366.2019.1574297 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Yang, Jie
Zhang, Pingping
Hu, Yuheng
Liu, Teng
Sun, Jie
Wang, Xiaojing
Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents
title Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents
title_full Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents
title_fullStr Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents
title_full_unstemmed Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents
title_short Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents
title_sort synthesis and biological evaluation of 3-arylcoumarins as potential anti-alzheimer's disease agents
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374920/
https://www.ncbi.nlm.nih.gov/pubmed/30746966
http://dx.doi.org/10.1080/14756366.2019.1574297
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