Opposing Roles of apolipoprotein E in aging and neurodegeneration

Apolipoprotein E (APOE) effects on brain function remain controversial. Removal of APOE not only impairs cognitive functions but also reduces neuritic amyloid plaques in mouse models of Alzheimer’s disease (AD). Can APOE simultaneously protect and impair neural circuits? Here, we dissociated the rol...

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Detalles Bibliográficos
Autores principales: Hudry, Eloise, Klickstein, Jacob, Cannavo, Claudia, Jackson, Rosemary, Muzikansky, Alona, Gandhi, Sheetal, Urick, David, Sargent, Taylie, Wrobleski, Lauren, Roe, Allyson D, Hou, Steven S, Kuchibhotla, Kishore V, Betensky, Rebecca A, Spires-Jones, Tara, Hyman, Bradley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374993/
https://www.ncbi.nlm.nih.gov/pubmed/30760557
http://dx.doi.org/10.26508/lsa.201900325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374993/
https://www.ncbi.nlm.nih.gov/pubmed/30760557
http://dx.doi.org/10.26508/lsa.201900325

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