Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. The mechanisms underlying the structural transition of soluble and innocuous α-syn to aggregated neurotoxic forms remains largely unknown. The di...

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Detalles Bibliográficos
Autores principales: Carija, Anita, Pinheiro, Francisca, Pujols, Jordi, Brás, Inês C., Lázaro, Diana Fernandes, Santambrogio, Carlo, Grandori, Rita, Outeiro, Tiago F., Navarro, Susanna, Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375061/
https://www.ncbi.nlm.nih.gov/pubmed/30769283
http://dx.doi.org/10.1016/j.redox.2019.101135

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