Cargando…

Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A Systematic Review

Background: Cardiac muscle possesses a limited capacity to regenerate its tissue on its own. It is less likely to reverse the altered cardiac functioning to its normal physiological state after a major myocardial infarction. Stem cell transplantation provided a unique therapeutic approach in managin...

Descripción completa

Detalles Bibliográficos
Autores principales: Bareeqa, Syeda Beenish, Bibi, Fazeela, Ahmed, Syed Ijlal, Samar, Syeda Sana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375372/
https://www.ncbi.nlm.nih.gov/pubmed/30774828
_version_ 1783395364165910528
author Bareeqa, Syeda Beenish
Bibi, Fazeela
Ahmed, Syed Ijlal
Samar, Syeda Sana
author_facet Bareeqa, Syeda Beenish
Bibi, Fazeela
Ahmed, Syed Ijlal
Samar, Syeda Sana
author_sort Bareeqa, Syeda Beenish
collection PubMed
description Background: Cardiac muscle possesses a limited capacity to regenerate its tissue on its own. It is less likely to reverse the altered cardiac functioning to its normal physiological state after a major myocardial infarction. Stem cell transplantation provided a unique therapeutic approach in managing such injuries. There has been a substantial debate about the complexity, scope and medical application of stem cell transplantation in past few years. Materials and Methods: An extensive review of medical literature was conducted to establish the consensus about the possible mechanism of cell renewal, associated complications and risks of failure of this technique. Twenty cases of mammalian animals and twenty-four cases of stem cell transplantation in human subjects were reviewed. Results: Most common associated complication was re-stenosis of coronary artery. Few clinical trials reported the failure in improving cardiac functioning. The success rate of stem cell transplantation was remarkable in the literature related to experimental animal subjects. Conclusion: It was concluded that renewal of the cardiac cell is a result of induction of angiogenesis and prolonged cell survival. This topic still requires an immense amount of research to fill the gap in adequate knowledge.
format Online
Article
Text
id pubmed-6375372
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center
record_format MEDLINE/PubMed
spelling pubmed-63753722019-02-15 Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A Systematic Review Bareeqa, Syeda Beenish Bibi, Fazeela Ahmed, Syed Ijlal Samar, Syeda Sana Int J Hematol Oncol Stem Cell Res Review Article Background: Cardiac muscle possesses a limited capacity to regenerate its tissue on its own. It is less likely to reverse the altered cardiac functioning to its normal physiological state after a major myocardial infarction. Stem cell transplantation provided a unique therapeutic approach in managing such injuries. There has been a substantial debate about the complexity, scope and medical application of stem cell transplantation in past few years. Materials and Methods: An extensive review of medical literature was conducted to establish the consensus about the possible mechanism of cell renewal, associated complications and risks of failure of this technique. Twenty cases of mammalian animals and twenty-four cases of stem cell transplantation in human subjects were reviewed. Results: Most common associated complication was re-stenosis of coronary artery. Few clinical trials reported the failure in improving cardiac functioning. The success rate of stem cell transplantation was remarkable in the literature related to experimental animal subjects. Conclusion: It was concluded that renewal of the cardiac cell is a result of induction of angiogenesis and prolonged cell survival. This topic still requires an immense amount of research to fill the gap in adequate knowledge. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2018-10-01 /pmc/articles/PMC6375372/ /pubmed/30774828 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bareeqa, Syeda Beenish
Bibi, Fazeela
Ahmed, Syed Ijlal
Samar, Syeda Sana
Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A Systematic Review
title Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A Systematic Review
title_full Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A Systematic Review
title_fullStr Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A Systematic Review
title_full_unstemmed Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A Systematic Review
title_short Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A Systematic Review
title_sort advancement in stem cell therapy for ischemic myocardial cell: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375372/
https://www.ncbi.nlm.nih.gov/pubmed/30774828
work_keys_str_mv AT bareeqasyedabeenish advancementinstemcelltherapyforischemicmyocardialcellasystematicreview
AT bibifazeela advancementinstemcelltherapyforischemicmyocardialcellasystematicreview
AT ahmedsyedijlal advancementinstemcelltherapyforischemicmyocardialcellasystematicreview
AT samarsyedasana advancementinstemcelltherapyforischemicmyocardialcellasystematicreview