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The Relationship between Fatigue and Cytokine Levels in Patients with Acute Myeloid Leukemia

Background: Cancer-related fatigue (CRF) is a very prominent complaint and disabling symptom in cancer patients probably influenced by endogenous cytokines. But, the published data on this subject are limited. We explored the relationship of cytokines such as tumor necrosis factor (TNF-α) and interl...

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Autores principales: Khosravi, Malihe, Taghvaye Masoumi, Hamidreza, Gholami, Kheirollah, Vaezi, Mohammad, Hadjibabaei, Molouk, Ghavamzadeh, Ardeshir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375377/
https://www.ncbi.nlm.nih.gov/pubmed/30774833
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author Khosravi, Malihe
Taghvaye Masoumi, Hamidreza
Gholami, Kheirollah
Vaezi, Mohammad
Hadjibabaei, Molouk
Ghavamzadeh, Ardeshir
author_facet Khosravi, Malihe
Taghvaye Masoumi, Hamidreza
Gholami, Kheirollah
Vaezi, Mohammad
Hadjibabaei, Molouk
Ghavamzadeh, Ardeshir
author_sort Khosravi, Malihe
collection PubMed
description Background: Cancer-related fatigue (CRF) is a very prominent complaint and disabling symptom in cancer patients probably influenced by endogenous cytokines. But, the published data on this subject are limited. We explored the relationship of cytokines such as tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) with fatigue in patients with AML. Materials and Methods: This study was performed on 45 patients (25 men, 20 women) with newly diagnosed AML. We examined fatigue in these patients with validated questionnaire. Simultaneously, blood samples were obtained for quantitative measurement of IL-6 and TNF-α. Results: Our results showed a positive correlation between fatigue and circulating levels of IL-6 (P=0.004, R=0.416). Conclusion: Many patients with AML experienced severe fatigue before the onset of treatment, which is not related to their hemoglobin (Hb) levels. Cytokine levels may be beneficial markers in resistance to fatigue, but further studies are needed before considering targeted therapies as a treatment for CRF.
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spelling pubmed-63753772019-02-15 The Relationship between Fatigue and Cytokine Levels in Patients with Acute Myeloid Leukemia Khosravi, Malihe Taghvaye Masoumi, Hamidreza Gholami, Kheirollah Vaezi, Mohammad Hadjibabaei, Molouk Ghavamzadeh, Ardeshir Int J Hematol Oncol Stem Cell Res Original Article Background: Cancer-related fatigue (CRF) is a very prominent complaint and disabling symptom in cancer patients probably influenced by endogenous cytokines. But, the published data on this subject are limited. We explored the relationship of cytokines such as tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) with fatigue in patients with AML. Materials and Methods: This study was performed on 45 patients (25 men, 20 women) with newly diagnosed AML. We examined fatigue in these patients with validated questionnaire. Simultaneously, blood samples were obtained for quantitative measurement of IL-6 and TNF-α. Results: Our results showed a positive correlation between fatigue and circulating levels of IL-6 (P=0.004, R=0.416). Conclusion: Many patients with AML experienced severe fatigue before the onset of treatment, which is not related to their hemoglobin (Hb) levels. Cytokine levels may be beneficial markers in resistance to fatigue, but further studies are needed before considering targeted therapies as a treatment for CRF. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2018-10-01 /pmc/articles/PMC6375377/ /pubmed/30774833 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khosravi, Malihe
Taghvaye Masoumi, Hamidreza
Gholami, Kheirollah
Vaezi, Mohammad
Hadjibabaei, Molouk
Ghavamzadeh, Ardeshir
The Relationship between Fatigue and Cytokine Levels in Patients with Acute Myeloid Leukemia
title The Relationship between Fatigue and Cytokine Levels in Patients with Acute Myeloid Leukemia
title_full The Relationship between Fatigue and Cytokine Levels in Patients with Acute Myeloid Leukemia
title_fullStr The Relationship between Fatigue and Cytokine Levels in Patients with Acute Myeloid Leukemia
title_full_unstemmed The Relationship between Fatigue and Cytokine Levels in Patients with Acute Myeloid Leukemia
title_short The Relationship between Fatigue and Cytokine Levels in Patients with Acute Myeloid Leukemia
title_sort relationship between fatigue and cytokine levels in patients with acute myeloid leukemia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375377/
https://www.ncbi.nlm.nih.gov/pubmed/30774833
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