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Alternative (backdoor) androgen production and masculinization in the human fetus
Masculinization of the external genitalia in humans is dependent on formation of 5α-dihydrotestosterone (DHT) through both the canonical androgenic pathway and an alternative (backdoor) pathway. The fetal testes are essential for canonical androgen production, but little is known about the synthesis...
Autores principales: | O’Shaughnessy, Peter J., Antignac, Jean Philippe, Le Bizec, Bruno, Morvan, Marie-Line, Svechnikov, Konstantin, Söder, Olle, Savchuk, Iuliia, Monteiro, Ana, Soffientini, Ugo, Johnston, Zoe C., Bellingham, Michelle, Hough, Denise, Walker, Natasha, Filis, Panagiotis, Fowler, Paul A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375548/ https://www.ncbi.nlm.nih.gov/pubmed/30763313 http://dx.doi.org/10.1371/journal.pbio.3000002 |
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