Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring

Local translation is rapidly regulated by extrinsic signals during neural wiring, but its control mechanisms remain elusive. Here we show that the extracellular cue Sema3A induces an initial burst in local translation that precisely controls phosphorylation of the translation initiation factor eIF2α...

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Detalles Bibliográficos
Autores principales: Cagnetta, Roberta, Wong, Hovy Ho-Wai, Frese, Christian K., Mallucci, Giovanna R., Krijgsveld, Jeroen, Holt, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375727/
https://www.ncbi.nlm.nih.gov/pubmed/30595434
http://dx.doi.org/10.1016/j.molcel.2018.11.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375727/
https://www.ncbi.nlm.nih.gov/pubmed/30595434
http://dx.doi.org/10.1016/j.molcel.2018.11.013

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