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Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring
Local translation is rapidly regulated by extrinsic signals during neural wiring, but its control mechanisms remain elusive. Here we show that the extracellular cue Sema3A induces an initial burst in local translation that precisely controls phosphorylation of the translation initiation factor eIF2α...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375727/ https://www.ncbi.nlm.nih.gov/pubmed/30595434 http://dx.doi.org/10.1016/j.molcel.2018.11.013 |