Cargando…

Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts

DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in S phase removal of DPCs, but how SPRTN is targeted to DPCs during DNA replication is unknown. Using Xenopus egg extracts...

Descripción completa

Detalles Bibliográficos
Autores principales:	Larsen, Nicolai B., Gao, Alan O., Sparks, Justin L., Gallina, Irene, Wu, R. Alex, Mann, Matthias, Räschle, Markus, Walter, Johannes C., Duxin, Julien P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375733/ https://www.ncbi.nlm.nih.gov/pubmed/30595436 http://dx.doi.org/10.1016/j.molcel.2018.11.024

Ejemplares similares

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair
por: Vaz, Bruno, et al.
Publicado: (2016)

Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease
por: Perry, Megan, et al.
Publicado: (2022)

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN
por: Stingele, Julian, et al.
Publicado: (2016)

The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
por: Ruggiano, Annamaria, et al.
Publicado: (2021)

SPRTN patient variants cause global-genome DNA-protein crosslink repair defects
por: Weickert, Pedro, et al.
Publicado: (2023)

DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease
por: Reinking, Hannah K., et al.
Publicado: (2020)

A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN
por: Zhao, Shubo, et al.
Publicado: (2020)

SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks
por: Lopez-Mosqueda, Jaime, et al.
Publicado: (2016)

Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway
por: Liu, Julio C Y, et al.
Publicado: (2021)

Replication-Fork Stalling and Processing at a Single Psoralen Interstrand Crosslink in Xenopus Egg Extracts
por: Le Breton, Cyrille, et al.
Publicado: (2011)

A model of DNA damage response activation at stalled replication forks by SPRTN
por: Bruhn, Christopher, et al.
Publicado: (2019)

Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN
por: Kröning, Alexander, et al.
Publicado: (2022)

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
por: Halder, Swagata, et al.
Publicado: (2019)

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA–protein crosslinks in vivo
por: Anticevic, Ivan, et al.
Publicado: (2023)

DNA damage-induced replication arrest in Xenopus egg extracts
por: Stokes, Matthew P., et al.
Publicado: (2003)

How to fix DNA-protein crosslinks
por: Kühbacher, Ulrike, et al.
Publicado: (2020)

Dynamics of the Eukaryotic Replicative Helicase at Lagging-Strand Protein Barriers Support the Steric Exclusion Model
por: Kose, Hazal B., et al.
Publicado: (2019)

The nuclear membrane determines the timing of DNA replication in Xenopus egg extracts
Publicado: (1991)

SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells
por: Na, Juri, et al.
Publicado: (2021)

USP11 mediates repair of DNA–protein cross-links by deubiquitinating SPRTN metalloprotease
por: Perry, Megan, et al.
Publicado: (2021)

Targeting DNA-Protein Crosslinks via Post-Translational Modifications
por: Leng, Xueyuan, et al.
Publicado: (2022)

DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts
por: Labit, Hélène, et al.
Publicado: (2008)

DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts
por: Stokes, Matthew P., et al.
Publicado: (2002)

DNA is a co-factor for its own replication in Xenopus egg extracts
por: Lebofsky, Ronald, et al.
Publicado: (2011)

Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts
por: Taylor, Elaine M., et al.
Publicado: (2013)

Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts
por: Recolin, Bénédicte, et al.
Publicado: (2012)

Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins
por: Gillespie, Peter J., et al.
Publicado: (2012)

Organization of DNA Replication Origin Firing in Xenopus Egg Extracts: The Role of Intra-S Checkpoint
por: Ciardo, Diletta, et al.
Publicado: (2021)

Non-homologous end joining repair in Xenopus egg extract
por: Zhu, Songli, et al.
Publicado: (2016)

SPRTN-dependent DPC degradation precedes repair of damaged DNA: a proof of concept revealed by the STAR assay
por: Glumac, Mateo, et al.
Publicado: (2023)

De novo assembly of genuine replication forks on an immobilized circular plasmid in Xenopus egg extracts
por: Zembutsu, Akiko, et al.
Publicado: (2006)

Chromosome architecture can dictate site-specific initiation of DNA replication in Xenopus egg extracts
Publicado: (1996)

Steps in the assembly of replication-competent nuclei in a cell-free system from Xenopus eggs
Publicado: (1988)

Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts
por: Leach, Craig A., et al.
Publicado: (2005)

SCAI promotes error‐free repair of DNA interstrand crosslinks via the Fanconi anemia pathway
por: Schubert, Lisa, et al.
Publicado: (2022)

DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network
por: Karanja, Kenneth K., et al.
Publicado: (2012)

Xenopus laevis lectin is localized at several sites in Xenopus oocytes, eggs, and embryos
Publicado: (1983)

Identification of nuclear pre-replication centers poised for DNA synthesis in Xenopus egg extracts: immunolocalization study of replication protein A
Publicado: (1992)

Determination of initiation of DNA replication before and after nuclear formation in Xenopus egg cell free extracts
Publicado: (1993)

The ubiquitin ligase RFWD3 is required for translesion DNA synthesis
por: Gallina, Irene, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_go589959irskrjchtgkn6h0c5a