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Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts

DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in S phase removal of DPCs, but how SPRTN is targeted to DPCs during DNA replication is unknown. Using Xenopus egg extracts...

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Detalles Bibliográficos
Autores principales:	Larsen, Nicolai B., Gao, Alan O., Sparks, Justin L., Gallina, Irene, Wu, R. Alex, Mann, Matthias, Räschle, Markus, Walter, Johannes C., Duxin, Julien P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375733/ https://www.ncbi.nlm.nih.gov/pubmed/30595436 http://dx.doi.org/10.1016/j.molcel.2018.11.024

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