Helicase Subunit Cdc45 Targets the Checkpoint Kinase Rad53 to Both Replication Initiation and Elongation Complexes after Fork Stalling

Across eukaryotes, disruption of DNA replication causes an S phase checkpoint response, which regulates multiple processes, including inhibition of replication initiation and fork stabilization. How these events are coordinated remains poorly understood. Here, we show that the replicative helicase c...

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Detalles Bibliográficos
Autores principales: Can, Geylani, Kauerhof, Anastasia Christine, Macak, Dominik, Zegerman, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375734/
https://www.ncbi.nlm.nih.gov/pubmed/30595439
http://dx.doi.org/10.1016/j.molcel.2018.11.025

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