Aggregation-Induced Emission: Lighting Up hERG Potassium Channel

Based on the scaffold of astemizole and E-4031, four AIE light-up probes (L1–L4) for Human Ether-a-go-go-Related Gene (hERG) potassium channel were developed herein using AIE fluorogen(TPE). These probes showing advantages such as low background interference, superior photostability, acceptable cell...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaomeng, Liu, Tingting, Li, Qi, Li, Minyong, Du, Lupei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375833/
https://www.ncbi.nlm.nih.gov/pubmed/30800649
http://dx.doi.org/10.3389/fchem.2019.00054
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author Zhang, Xiaomeng
Liu, Tingting
Li, Qi
Li, Minyong
Du, Lupei
author_facet Zhang, Xiaomeng
Liu, Tingting
Li, Qi
Li, Minyong
Du, Lupei
author_sort Zhang, Xiaomeng
collection PubMed
description Based on the scaffold of astemizole and E-4031, four AIE light-up probes (L1–L4) for Human Ether-a-go-go-Related Gene (hERG) potassium channel were developed herein using AIE fluorogen(TPE). These probes showing advantages such as low background interference, superior photostability, acceptable cell toxicity, and potent inhibitory activity, which could be used to image hERG channels at the nanomolar level. These AIE light-up probes hoped to provide guidelines for the design of more advanced AIE sensing and imaging hERG channels to a broad range of applications.
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spelling pubmed-63758332019-02-22 Aggregation-Induced Emission: Lighting Up hERG Potassium Channel Zhang, Xiaomeng Liu, Tingting Li, Qi Li, Minyong Du, Lupei Front Chem Chemistry Based on the scaffold of astemizole and E-4031, four AIE light-up probes (L1–L4) for Human Ether-a-go-go-Related Gene (hERG) potassium channel were developed herein using AIE fluorogen(TPE). These probes showing advantages such as low background interference, superior photostability, acceptable cell toxicity, and potent inhibitory activity, which could be used to image hERG channels at the nanomolar level. These AIE light-up probes hoped to provide guidelines for the design of more advanced AIE sensing and imaging hERG channels to a broad range of applications. Frontiers Media S.A. 2019-02-08 /pmc/articles/PMC6375833/ /pubmed/30800649 http://dx.doi.org/10.3389/fchem.2019.00054 Text en Copyright © 2019 Zhang, Liu, Li, Li and Du. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Zhang, Xiaomeng
Liu, Tingting
Li, Qi
Li, Minyong
Du, Lupei
Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
title Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
title_full Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
title_fullStr Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
title_full_unstemmed Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
title_short Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
title_sort aggregation-induced emission: lighting up herg potassium channel
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375833/
https://www.ncbi.nlm.nih.gov/pubmed/30800649
http://dx.doi.org/10.3389/fchem.2019.00054
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AT liutingting aggregationinducedemissionlightinguphergpotassiumchannel
AT liqi aggregationinducedemissionlightinguphergpotassiumchannel
AT liminyong aggregationinducedemissionlightinguphergpotassiumchannel
AT dulupei aggregationinducedemissionlightinguphergpotassiumchannel

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