MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence GNRH1 Expression

Paternally-inherited loss-of-function mutations in makorin ring finger protein 3 gene (MKRN3) underlie central precocious puberty. To investigate the puberty-related mechanism(s) of MKRN3 in humans, we generated two distinct bi-allelic MKRN3 knock-out human pluripotent stem cell lines, Del 1 and Del...

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Detalles Bibliográficos
Autores principales: Yellapragada, Venkatram, Liu, Xiaonan, Lund, Carina, Känsäkoski, Johanna, Pulli, Kristiina, Vuoristo, Sanna, Lundin, Karolina, Tuuri, Timo, Varjosalo, Markku, Raivio, Taneli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375840/
https://www.ncbi.nlm.nih.gov/pubmed/30800097
http://dx.doi.org/10.3389/fendo.2019.00048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375840/
https://www.ncbi.nlm.nih.gov/pubmed/30800097
http://dx.doi.org/10.3389/fendo.2019.00048

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