Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol

Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among th...

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Detalles Bibliográficos
Autores principales: Cassiano, Chiara, Esposito, Roberta, Tosco, Alessandra, Casapullo, Agostino, Mozzicafreddo, Matteo, Tringali, Corrado, Riccio, Raffaele, Monti, Maria Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375844/
https://www.ncbi.nlm.nih.gov/pubmed/30800648
http://dx.doi.org/10.3389/fchem.2019.00053
Descripción
Sumario:Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays.

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