Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol

Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among th...

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Autores principales: Cassiano, Chiara, Esposito, Roberta, Tosco, Alessandra, Casapullo, Agostino, Mozzicafreddo, Matteo, Tringali, Corrado, Riccio, Raffaele, Monti, Maria Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375844/
https://www.ncbi.nlm.nih.gov/pubmed/30800648
http://dx.doi.org/10.3389/fchem.2019.00053
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author Cassiano, Chiara
Esposito, Roberta
Tosco, Alessandra
Casapullo, Agostino
Mozzicafreddo, Matteo
Tringali, Corrado
Riccio, Raffaele
Monti, Maria Chiara
author_facet Cassiano, Chiara
Esposito, Roberta
Tosco, Alessandra
Casapullo, Agostino
Mozzicafreddo, Matteo
Tringali, Corrado
Riccio, Raffaele
Monti, Maria Chiara
author_sort Cassiano, Chiara
collection PubMed
description Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays.
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spelling pubmed-63758442019-02-22 Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol Cassiano, Chiara Esposito, Roberta Tosco, Alessandra Casapullo, Agostino Mozzicafreddo, Matteo Tringali, Corrado Riccio, Raffaele Monti, Maria Chiara Front Chem Chemistry Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays. Frontiers Media S.A. 2019-02-08 /pmc/articles/PMC6375844/ /pubmed/30800648 http://dx.doi.org/10.3389/fchem.2019.00053 Text en Copyright © 2019 Cassiano, Esposito, Tosco, Casapullo, Mozzicafreddo, Tringali, Riccio and Monti. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Cassiano, Chiara
Esposito, Roberta
Tosco, Alessandra
Casapullo, Agostino
Mozzicafreddo, Matteo
Tringali, Corrado
Riccio, Raffaele
Monti, Maria Chiara
Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol
title Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol
title_full Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol
title_fullStr Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol
title_full_unstemmed Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol
title_short Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol
title_sort chemical proteomics-guided identification of a novel biological target of the bioactive neolignan magnolol
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375844/
https://www.ncbi.nlm.nih.gov/pubmed/30800648
http://dx.doi.org/10.3389/fchem.2019.00053
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