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Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites

The synergy between gelator molecules and nanostructured materials is currently a novel matter of study. The possibility to carefully design the skeleton of the molecular entity as well as the nanostructure's morphological and chemical features offers the possibility to prepare a huge variety o...

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Autores principales: Dalmases, Mariona, Pinto, Andrea, Lippmann, Petra, Ott, Ingo, Rodríguez, Laura, Figuerola, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375849/
https://www.ncbi.nlm.nih.gov/pubmed/30800652
http://dx.doi.org/10.3389/fchem.2019.00060
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author Dalmases, Mariona
Pinto, Andrea
Lippmann, Petra
Ott, Ingo
Rodríguez, Laura
Figuerola, Albert
author_facet Dalmases, Mariona
Pinto, Andrea
Lippmann, Petra
Ott, Ingo
Rodríguez, Laura
Figuerola, Albert
author_sort Dalmases, Mariona
collection PubMed
description The synergy between gelator molecules and nanostructured materials is currently a novel matter of study. The possibility to carefully design the skeleton of the molecular entity as well as the nanostructure's morphological and chemical features offers the possibility to prepare a huge variety of nanocomposites with properties potentially different than just the sum of those of the individual building blocks. Here we describe the synthesis and characterization of nanocomposites made by the unconventional combination of phosphine-Au(I)-alkynyl-based organometallic gelating molecules and plasmonic Au nanoparticles. Our results indicate that the interaction between the two moieties leads to a significant degree of aggregation in both hydrophilic and hydrophobic media, either when using DAPTA or PTA-based organometallic molecules, with the formation of a sponge-like hybrid powder upon solvent evaporation. The biological activity of the nanocomposites was assessed, suggesting the existence of a synergetic effect evidenced by the higher cytotoxicity of the hybrid systems with respect to that of any of their isolated counterparts. These results represent a preliminary proof-of-concept for the exploitation of these novel nanocomposites in the biomedical field.
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spelling pubmed-63758492019-02-22 Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites Dalmases, Mariona Pinto, Andrea Lippmann, Petra Ott, Ingo Rodríguez, Laura Figuerola, Albert Front Chem Chemistry The synergy between gelator molecules and nanostructured materials is currently a novel matter of study. The possibility to carefully design the skeleton of the molecular entity as well as the nanostructure's morphological and chemical features offers the possibility to prepare a huge variety of nanocomposites with properties potentially different than just the sum of those of the individual building blocks. Here we describe the synthesis and characterization of nanocomposites made by the unconventional combination of phosphine-Au(I)-alkynyl-based organometallic gelating molecules and plasmonic Au nanoparticles. Our results indicate that the interaction between the two moieties leads to a significant degree of aggregation in both hydrophilic and hydrophobic media, either when using DAPTA or PTA-based organometallic molecules, with the formation of a sponge-like hybrid powder upon solvent evaporation. The biological activity of the nanocomposites was assessed, suggesting the existence of a synergetic effect evidenced by the higher cytotoxicity of the hybrid systems with respect to that of any of their isolated counterparts. These results represent a preliminary proof-of-concept for the exploitation of these novel nanocomposites in the biomedical field. Frontiers Media S.A. 2019-02-08 /pmc/articles/PMC6375849/ /pubmed/30800652 http://dx.doi.org/10.3389/fchem.2019.00060 Text en Copyright © 2019 Dalmases, Pinto, Lippmann, Ott, Rodríguez and Figuerola. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Dalmases, Mariona
Pinto, Andrea
Lippmann, Petra
Ott, Ingo
Rodríguez, Laura
Figuerola, Albert
Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites
title Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites
title_full Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites
title_fullStr Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites
title_full_unstemmed Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites
title_short Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites
title_sort preparation and antitumoral activity of au-based inorganic-organometallic nanocomposites
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375849/
https://www.ncbi.nlm.nih.gov/pubmed/30800652
http://dx.doi.org/10.3389/fchem.2019.00060
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