PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185(erbB2/neu) Tumor Immunotherapy

Regulatory T cells (Tregs) are a subpopulation of T cells that are specialized in suppressing immune responses. Here we show that the arginine methyl transferase protein PRMT5 can complex with FOXP3 transcription factors in Tregs. Mice with conditional knock out (cKO) of PRMT5 expression in Tregs de...

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Detalles Bibliográficos
Autores principales: Nagai, Yasuhiro, Ji, Mei Q., Zhu, Fuxiang, Xiao, Yan, Tanaka, Yukinori, Kambayashi, Taku, Fujimoto, Shigeyoshi, Goldberg, Michael M., Zhang, Hongtao, Li, Bin, Ohtani, Takuya, Greene, Mark I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375878/
https://www.ncbi.nlm.nih.gov/pubmed/30800128
http://dx.doi.org/10.3389/fimmu.2019.00174

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