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Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses

IL-17 produced by Th17 cells has been implicated in the pathogenesis of rheumatoid arthritis (RA). It is important to prevent the differentiation of Th17 cells in RA. Homodimeric soluble γc (sγc) impairs IL-2 signaling and enhances Th17 differentiation. Thus, we aimed to block the functions of sγc b...

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Detalles Bibliográficos
Autores principales:	Lee, Byunghyuk, Jo, Yuna, Kim, Geona, Ali, Laraib Amir, Sohn, Dong Hyun, Lee, Seung-Geun, Kim, Kiseok, Shin, Euisu, Ryu, Sung Ho, Hong, Changwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375885/ https://www.ncbi.nlm.nih.gov/pubmed/30800133 http://dx.doi.org/10.3389/fimmu.2019.00209

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