The Role of NMDA Receptors in Alzheimer’s Disease

In Alzheimer’s disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. Ho...

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Detalles Bibliográficos
Autores principales: Liu, Jinping, Chang, Lirong, Song, Yizhi, Li, Hui, Wu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375899/
https://www.ncbi.nlm.nih.gov/pubmed/30800052
http://dx.doi.org/10.3389/fnins.2019.00043
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author Liu, Jinping
Chang, Lirong
Song, Yizhi
Li, Hui
Wu, Yan
author_facet Liu, Jinping
Chang, Lirong
Song, Yizhi
Li, Hui
Wu, Yan
author_sort Liu, Jinping
collection PubMed
description In Alzheimer’s disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. However, clear evidence is still deficient in demonstrating the underlying mechanisms and a relationship between NMDARs dysfunction and AD. This review focuses on not only changes in expression of different NMDAR subunits, but also some unconventional modes of NMDAR action.
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spelling pubmed-63758992019-02-22 The Role of NMDA Receptors in Alzheimer’s Disease Liu, Jinping Chang, Lirong Song, Yizhi Li, Hui Wu, Yan Front Neurosci Neuroscience In Alzheimer’s disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. However, clear evidence is still deficient in demonstrating the underlying mechanisms and a relationship between NMDARs dysfunction and AD. This review focuses on not only changes in expression of different NMDAR subunits, but also some unconventional modes of NMDAR action. Frontiers Media S.A. 2019-02-08 /pmc/articles/PMC6375899/ /pubmed/30800052 http://dx.doi.org/10.3389/fnins.2019.00043 Text en Copyright © 2019 Liu, Chang, Song, Li and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Jinping
Chang, Lirong
Song, Yizhi
Li, Hui
Wu, Yan
The Role of NMDA Receptors in Alzheimer’s Disease
title The Role of NMDA Receptors in Alzheimer’s Disease
title_full The Role of NMDA Receptors in Alzheimer’s Disease
title_fullStr The Role of NMDA Receptors in Alzheimer’s Disease
title_full_unstemmed The Role of NMDA Receptors in Alzheimer’s Disease
title_short The Role of NMDA Receptors in Alzheimer’s Disease
title_sort role of nmda receptors in alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375899/
https://www.ncbi.nlm.nih.gov/pubmed/30800052
http://dx.doi.org/10.3389/fnins.2019.00043
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