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The Role of NMDA Receptors in Alzheimer’s Disease

In Alzheimer’s disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. Ho...

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Detalles Bibliográficos
Autores principales:	Liu, Jinping, Chang, Lirong, Song, Yizhi, Li, Hui, Wu, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375899/ https://www.ncbi.nlm.nih.gov/pubmed/30800052 http://dx.doi.org/10.3389/fnins.2019.00043

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