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Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography
Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tis...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375924/ https://www.ncbi.nlm.nih.gov/pubmed/30765763 http://dx.doi.org/10.1038/s41598-019-38493-y |
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author | Yashin, Konstantin S. Kiseleva, Elena B. Moiseev, Alexander A. Kuznetsov, Sergey S. Timofeeva, Lidia B. Pavlova, Nadezhda P. Gelikonov, Grigory V. Medyanik, Igor А. Kravets, Leonid Ya. Zagaynova, Elena V. Gladkova, Natalia D. |
author_facet | Yashin, Konstantin S. Kiseleva, Elena B. Moiseev, Alexander A. Kuznetsov, Sergey S. Timofeeva, Lidia B. Pavlova, Nadezhda P. Gelikonov, Grigory V. Medyanik, Igor А. Kravets, Leonid Ya. Zagaynova, Elena V. Gladkova, Natalia D. |
author_sort | Yashin, Konstantin S. |
collection | PubMed |
description | Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter, tumorous tissue without necrotic areas had significantly lower optical attenuation and forward cross-scattering values. The presence of particular morphological patterns, such as necrosis and injured myelinated fibers, can lead to dramatic changes in coefficient values and create some difficulties in differentiating between tissues. Color-coded CP OCT maps based on optical coefficients provided a visual assessment of the tissue. This study demonstrated the high translational potential of CP OCT in differentiating tumorous tissue from white matter. The clinical use of CP OCT during surgery in patients with gliomas could increase the extent of tumor resection and improve overall and progression-free survival. |
format | Online Article Text |
id | pubmed-6375924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63759242019-02-19 Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography Yashin, Konstantin S. Kiseleva, Elena B. Moiseev, Alexander A. Kuznetsov, Sergey S. Timofeeva, Lidia B. Pavlova, Nadezhda P. Gelikonov, Grigory V. Medyanik, Igor А. Kravets, Leonid Ya. Zagaynova, Elena V. Gladkova, Natalia D. Sci Rep Article Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter, tumorous tissue without necrotic areas had significantly lower optical attenuation and forward cross-scattering values. The presence of particular morphological patterns, such as necrosis and injured myelinated fibers, can lead to dramatic changes in coefficient values and create some difficulties in differentiating between tissues. Color-coded CP OCT maps based on optical coefficients provided a visual assessment of the tissue. This study demonstrated the high translational potential of CP OCT in differentiating tumorous tissue from white matter. The clinical use of CP OCT during surgery in patients with gliomas could increase the extent of tumor resection and improve overall and progression-free survival. Nature Publishing Group UK 2019-02-14 /pmc/articles/PMC6375924/ /pubmed/30765763 http://dx.doi.org/10.1038/s41598-019-38493-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yashin, Konstantin S. Kiseleva, Elena B. Moiseev, Alexander A. Kuznetsov, Sergey S. Timofeeva, Lidia B. Pavlova, Nadezhda P. Gelikonov, Grigory V. Medyanik, Igor А. Kravets, Leonid Ya. Zagaynova, Elena V. Gladkova, Natalia D. Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography |
title | Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography |
title_full | Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography |
title_fullStr | Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography |
title_full_unstemmed | Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography |
title_short | Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography |
title_sort | quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375924/ https://www.ncbi.nlm.nih.gov/pubmed/30765763 http://dx.doi.org/10.1038/s41598-019-38493-y |
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