PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1

Excessive or uncontrolled release of proinflammatory cytokines caused by severe viral infections often results in host tissue injury or even death. Phospholipase C (PLC)s degrade phosphatidylinositol-4, 5-bisphosphate (PI(4,5)P2) lipids and regulate multiple cellular events. Here, we report that PLC...

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Detalles Bibliográficos
Autores principales: Wang, Lin, Zhou, Yilong, Chen, Zijuan, Sun, Lei, Wu, Juehui, Li, Haohao, Liu, Feng, Wang, Fei, Yang, Chunfu, Yang, Juhao, Leng, Qibin, Zhang, Qingli, Xu, Ajing, Shen, Lisong, Sun, Jinqiao, Wu, Dianqing, Fang, Caiyun, Lu, Haojie, Yan, Dapeng, Ge, Baoxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375925/
https://www.ncbi.nlm.nih.gov/pubmed/30765691
http://dx.doi.org/10.1038/s41467-019-08524-3

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