Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury

The role of Endoplasmic Reticulum Chaperone and Signaling Regulator BiP/GRP78 in acute inflammatory injury, particularly in the context of lung endothelium, is poorly defined. In his study, we monitored the effect of SubAB, a holoenzyme that cleaves and specifically inactivates BiP/GRP78 and its ina...

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Detalles Bibliográficos
Autores principales: Leonard, Antony, Grose, Valerie, Paton, Adrienne W., Paton, James C., Yule, David I., Rahman, Arshad, Fazal, Fabeha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376000/
https://www.ncbi.nlm.nih.gov/pubmed/30765717
http://dx.doi.org/10.1038/s41598-018-38312-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376000/
https://www.ncbi.nlm.nih.gov/pubmed/30765717
http://dx.doi.org/10.1038/s41598-018-38312-w

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