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Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury

The role of Endoplasmic Reticulum Chaperone and Signaling Regulator BiP/GRP78 in acute inflammatory injury, particularly in the context of lung endothelium, is poorly defined. In his study, we monitored the effect of SubAB, a holoenzyme that cleaves and specifically inactivates BiP/GRP78 and its ina...

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Detalles Bibliográficos
Autores principales:	Leonard, Antony, Grose, Valerie, Paton, Adrienne W., Paton, James C., Yule, David I., Rahman, Arshad, Fazal, Fabeha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376000/ https://www.ncbi.nlm.nih.gov/pubmed/30765717 http://dx.doi.org/10.1038/s41598-018-38312-w

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