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The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses
The objective was to delineate hepatitis C virus (HCV) epidemiology in countries of Central Asia (CA), specifically Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. A systematic review was conducted guided by the Cochrane Collaboration Handbook, and reported using PRISMA guidelines....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376025/ https://www.ncbi.nlm.nih.gov/pubmed/30765844 http://dx.doi.org/10.1038/s41598-019-38853-8 |
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author | Botheju, Welathanthrige S. P. Zghyer, Fawzi Mahmud, Sarwat Terlikbayeva, Assel El-Bassel, Nabila Abu-Raddad, Laith J. |
author_facet | Botheju, Welathanthrige S. P. Zghyer, Fawzi Mahmud, Sarwat Terlikbayeva, Assel El-Bassel, Nabila Abu-Raddad, Laith J. |
author_sort | Botheju, Welathanthrige S. P. |
collection | PubMed |
description | The objective was to delineate hepatitis C virus (HCV) epidemiology in countries of Central Asia (CA), specifically Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. A systematic review was conducted guided by the Cochrane Collaboration Handbook, and reported using PRISMA guidelines. Meta-analyses were performed using DerSimonian-Laird random-effects models with inverse variance weighting. Random-effects meta-regression analyses were performed on general population studies. The systematic review identified a total of 208 HCV prevalence measures. No incidence or Turkmenistan studies were identified. Meta-analyses estimated HCV prevalence among the general population at 0.7% (95%CI: 0.7–0.8%) in Kazakhstan, 2.0% (95%CI: 1.7–2.4%) in Kyrgyzstan, 2.6% (95%CI: 1.7–3.6%) in Tajikistan, and 9.6 (95%CI: 5.8–14.2%) in Uzbekistan. Across CA, the pooled mean prevalence was 13.5% (95%CI: 10.9–16.4%) among non-specific clinical populations, 31.6% (95%CI: 25.8–37.7%) among populations with liver-related conditions, and 51.3% (95%CI: 46.9–55.6%) among people who inject drugs. Genotypes 1 (52.6%) and 3 (38.0%) were most frequent. Evidence was found for statistically-significant differences in prevalence by country, but not for a temporal decline in prevalence. CA is one of the most affected regions by HCV infection with Uzbekistan enduring one of the highest prevalence levels worldwide. Ongoing HCV transmission seems to be driven by injecting drug use and healthcare exposures. |
format | Online Article Text |
id | pubmed-6376025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63760252019-02-19 The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses Botheju, Welathanthrige S. P. Zghyer, Fawzi Mahmud, Sarwat Terlikbayeva, Assel El-Bassel, Nabila Abu-Raddad, Laith J. Sci Rep Article The objective was to delineate hepatitis C virus (HCV) epidemiology in countries of Central Asia (CA), specifically Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. A systematic review was conducted guided by the Cochrane Collaboration Handbook, and reported using PRISMA guidelines. Meta-analyses were performed using DerSimonian-Laird random-effects models with inverse variance weighting. Random-effects meta-regression analyses were performed on general population studies. The systematic review identified a total of 208 HCV prevalence measures. No incidence or Turkmenistan studies were identified. Meta-analyses estimated HCV prevalence among the general population at 0.7% (95%CI: 0.7–0.8%) in Kazakhstan, 2.0% (95%CI: 1.7–2.4%) in Kyrgyzstan, 2.6% (95%CI: 1.7–3.6%) in Tajikistan, and 9.6 (95%CI: 5.8–14.2%) in Uzbekistan. Across CA, the pooled mean prevalence was 13.5% (95%CI: 10.9–16.4%) among non-specific clinical populations, 31.6% (95%CI: 25.8–37.7%) among populations with liver-related conditions, and 51.3% (95%CI: 46.9–55.6%) among people who inject drugs. Genotypes 1 (52.6%) and 3 (38.0%) were most frequent. Evidence was found for statistically-significant differences in prevalence by country, but not for a temporal decline in prevalence. CA is one of the most affected regions by HCV infection with Uzbekistan enduring one of the highest prevalence levels worldwide. Ongoing HCV transmission seems to be driven by injecting drug use and healthcare exposures. Nature Publishing Group UK 2019-02-14 /pmc/articles/PMC6376025/ /pubmed/30765844 http://dx.doi.org/10.1038/s41598-019-38853-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Botheju, Welathanthrige S. P. Zghyer, Fawzi Mahmud, Sarwat Terlikbayeva, Assel El-Bassel, Nabila Abu-Raddad, Laith J. The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
title | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
title_full | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
title_fullStr | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
title_full_unstemmed | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
title_short | The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses |
title_sort | epidemiology of hepatitis c virus in central asia: systematic review, meta-analyses, and meta-regression analyses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376025/ https://www.ncbi.nlm.nih.gov/pubmed/30765844 http://dx.doi.org/10.1038/s41598-019-38853-8 |
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