Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug

The proprotein convertase PACE4 has been validated as a potential target to develop new therapeutic interventions in prostate cancer (PCa). So far, the most effective compound blocking the activity of this enzyme has been designed based on the structure of a small peptide Ac-LLLLRVKR-NH(2) known as...

Descripción completa

Detalles Bibliográficos
Autores principales: Kwiatkowska, Anna, Couture, Frédéric, Ait-Mohand, Samia, Desjardins, Roxane, Dory, Yves L., Guérin, Brigitte, Day, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376031/
https://www.ncbi.nlm.nih.gov/pubmed/30765725
http://dx.doi.org/10.1038/s41598-018-37568-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376031/
https://www.ncbi.nlm.nih.gov/pubmed/30765725
http://dx.doi.org/10.1038/s41598-018-37568-6

Ejemplares similares