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In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm

Aortic aneurysm is the most life-threatening complication in Marfan syndrome (MFS) patients. Doxycycline, a nonselective matrix metalloproteinases inhibitor, was reported to improve the contractile function and elastic fiber structure and organization in a Marfan mouse aorta using ex vivo small cham...

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Detalles Bibliográficos
Autores principales:	Cui, Jason Z., Lee, Ling, Sheng, Xiaoye, Chu, Fanny, Gibson, Christine P., Aydinian, Taline, Walker, David C., Sandor, George G. S., Bernatchez, Pascal, Tibbits, Glen F., van Breemen, Cornelis, Esfandiarei, Mitra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376062/ https://www.ncbi.nlm.nih.gov/pubmed/30765726 http://dx.doi.org/10.1038/s41598-018-38235-6

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