Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism against pathogens. However, the cellular self-protective mechanism against such potential damage from oxidative stress remains unclear. Here we show that the kinases Mst1 and Mst2 (Mst1/2) sense ROS and maintain cell...

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Detalles Bibliográficos
Autores principales: Wang, Ping, Geng, Jing, Gao, Jiahui, Zhao, Hao, Li, Junhong, Shi, Yiran, Yang, Bingying, Xiao, Chen, Linghu, Yueyue, Sun, Xiufeng, Chen, Xin, Hong, Lixin, Qin, Funiu, Li, Xun, Yu, Jau-Song, You, Han, Yuan, Zengqiang, Zhou, Dawang, Johnson, Randy L., Chen, Lanfen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376064/
https://www.ncbi.nlm.nih.gov/pubmed/30765703
http://dx.doi.org/10.1038/s41467-019-08680-6

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