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Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis

Chronic periodontitis (CP) is a common oral disease characterized by the slow progression of alveolar attachment loss and bone destruction. Genetic components have been reported to play an important role in the onset and development of CP. In the present study, we aimed to replicate the association...

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Autores principales: Tong, Hua, Wei, Zhuliang, Yin, Jing, Zhang, Bo, Zhang, Tianxiao, Deng, Chunni, Huang, Yali, Zhang, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376118/
https://www.ncbi.nlm.nih.gov/pubmed/30765789
http://dx.doi.org/10.1038/s41598-019-38632-5
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author Tong, Hua
Wei, Zhuliang
Yin, Jing
Zhang, Bo
Zhang, Tianxiao
Deng, Chunni
Huang, Yali
Zhang, Nan
author_facet Tong, Hua
Wei, Zhuliang
Yin, Jing
Zhang, Bo
Zhang, Tianxiao
Deng, Chunni
Huang, Yali
Zhang, Nan
author_sort Tong, Hua
collection PubMed
description Chronic periodontitis (CP) is a common oral disease characterized by the slow progression of alveolar attachment loss and bone destruction. Genetic components have been reported to play an important role in the onset and development of CP. In the present study, we aimed to replicate the association signals of NIN and SIGLEC5 identified in previous genome-wide association studies (GWASs) of samples from Chinese Han individuals. Association signals between clinical severity indicators of CP and relevant single nucleotide polymorphisms (SNPs) were also examined. A total of 3,160 study subjects, including 1,076 CP patients and 2,084 healthy controls, were recruited. A total of 32 SNPs, including 22 from NIN and 10 from SIGLEC5, were selected for genotyping. SNPs rs12883458 (OR = 1.45, P = 1.22 × 10(−5), NIN) and rs4284742 (OR = 0.75, P = 1.69 × 10(−5), SIGLEC5) were significantly associated with CP disease status. rs4284742 was significantly associated with all 3 clinical severity indicators, including bleeding on probing (BOP), probing depth (PD) and clinical attachment loss (CAL). According to evidence from bioinformatics analyses, both significant SNPs, rs12883458 and rs4284742, are likely surrogates of underlying variants with true effects. In summary, our findings provide direct evidence for the association of NIN and SIGLEC5 with CP susceptibility.
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spelling pubmed-63761182019-02-19 Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis Tong, Hua Wei, Zhuliang Yin, Jing Zhang, Bo Zhang, Tianxiao Deng, Chunni Huang, Yali Zhang, Nan Sci Rep Article Chronic periodontitis (CP) is a common oral disease characterized by the slow progression of alveolar attachment loss and bone destruction. Genetic components have been reported to play an important role in the onset and development of CP. In the present study, we aimed to replicate the association signals of NIN and SIGLEC5 identified in previous genome-wide association studies (GWASs) of samples from Chinese Han individuals. Association signals between clinical severity indicators of CP and relevant single nucleotide polymorphisms (SNPs) were also examined. A total of 3,160 study subjects, including 1,076 CP patients and 2,084 healthy controls, were recruited. A total of 32 SNPs, including 22 from NIN and 10 from SIGLEC5, were selected for genotyping. SNPs rs12883458 (OR = 1.45, P = 1.22 × 10(−5), NIN) and rs4284742 (OR = 0.75, P = 1.69 × 10(−5), SIGLEC5) were significantly associated with CP disease status. rs4284742 was significantly associated with all 3 clinical severity indicators, including bleeding on probing (BOP), probing depth (PD) and clinical attachment loss (CAL). According to evidence from bioinformatics analyses, both significant SNPs, rs12883458 and rs4284742, are likely surrogates of underlying variants with true effects. In summary, our findings provide direct evidence for the association of NIN and SIGLEC5 with CP susceptibility. Nature Publishing Group UK 2019-02-14 /pmc/articles/PMC6376118/ /pubmed/30765789 http://dx.doi.org/10.1038/s41598-019-38632-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tong, Hua
Wei, Zhuliang
Yin, Jing
Zhang, Bo
Zhang, Tianxiao
Deng, Chunni
Huang, Yali
Zhang, Nan
Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis
title Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis
title_full Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis
title_fullStr Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis
title_full_unstemmed Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis
title_short Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis
title_sort genetic susceptibility of common polymorphisms in nin and siglec5 to chronic periodontitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376118/
https://www.ncbi.nlm.nih.gov/pubmed/30765789
http://dx.doi.org/10.1038/s41598-019-38632-5
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