Antibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes

Antigen-antibody interaction is crucial in autoimmune disease pathogenesis, as multiple sclerosis and neuromyelitis optica. Given that, autoantibodies are essential biomolecules, of which the myelin oligodendrocyte glycoprotein (MOG) can figure as a target. Here we combined Molecular Dynamics (MD),...

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Detalles Bibliográficos
Autores principales: Ierich, Jéssica Cristiane Magalhães, Brum, Doralina Guimarães, Moraes, Ariana de Souza, Higa, Akemi Martins, Garcia, Pâmela Soto, Miyazaki, Celina Massumi, Ferreira, Marystela, Peroni, Luís Antonio, Oliveira, Guedmiller Souza de, Franca, Eduardo de Faria, Freitas, Luiz Carlos Gomide, Leite, Fabio Lima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376134/
https://www.ncbi.nlm.nih.gov/pubmed/30765742
http://dx.doi.org/10.1038/s41598-018-36578-8

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