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Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition

The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid. Quinolinic acid (QUIN) is an excitotoxic agonist at...

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Detalles Bibliográficos
Autores principales:	Phillips, Robert S., Iradukunda, Emma Carine, Hughes, Tamera, Bowen, J. Phillip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376250/ https://www.ncbi.nlm.nih.gov/pubmed/30800661 http://dx.doi.org/10.3389/fmolb.2019.00003

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