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Chondrosarcoma in a paediatric population: a study of 247 cases
PURPOSE: The aims of present study are to clarify the follow questions: 1) what constitutes paediatric chondrosarcoma?; 2) what are the effects of the demographic and tumour characteristics on survival in patients with paediatric chondrosarcoma?; 3) which prognostic factors of paediatric chondrosarc...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Editorial Society of Bone & Joint Surgery
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376431/ https://www.ncbi.nlm.nih.gov/pubmed/30838081 http://dx.doi.org/10.1302/1863-2548.13.180109 |
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author | Wu, A.-M. Li, G Zheng, J.-W. Chen, C.-H. Chen, D Qiao, Z.-G. Zhao, J.-G. Wang, B Fu, W.-L. Sheng, S.-R. Wu, Y.-S. Tian, N.-F. Lin, Z.-K. Xu, H |
author_facet | Wu, A.-M. Li, G Zheng, J.-W. Chen, C.-H. Chen, D Qiao, Z.-G. Zhao, J.-G. Wang, B Fu, W.-L. Sheng, S.-R. Wu, Y.-S. Tian, N.-F. Lin, Z.-K. Xu, H |
author_sort | Wu, A.-M. |
collection | PubMed |
description | PURPOSE: The aims of present study are to clarify the follow questions: 1) what constitutes paediatric chondrosarcoma?; 2) what are the effects of the demographic and tumour characteristics on survival in patients with paediatric chondrosarcoma?; 3) which prognostic factors of paediatric chondrosarcoma differ from those of the adult population, which have been reported previously? METHODS: Paediatric patients who were diagnosed with chondrosarcoma were searched for using the case listing session protocol of the National Cancer Institute’s Surveillance, Epidemiology, and End Results 18 databases (1973 to 2014). The extracted demographic information includes: age, race, gender, year of diagnosis, tumour sites, tumour histological subtype, grade, stage and treatment. RESULTS: A total of 247 paediatric chondrosarcoma patients were extracted and included in our present study. We find that the paediatric patients have significantly better survival rates than the adult patients. The year of diagnosis, tumour sites, tumour histological subtype, grade, stage and surgery received are independent prognostic factors for the survival rate of paediatric chondrosarcoma patients, but race, gender and age are not. CONCLUSION: The paediatric chondrosarcoma patients have better survival rates than the adults. Paediatric patients with a diagnosis at an early age, tumour site at the vertebral column and pelvis/sacrococcyx, myxoid variants, high grade, distant stage and who did not have surgery have a poorer prognosis than patients with a diagnosis at a later age, tumour site at limbs, head and base, chondrosarcoma not otherwise specified, lower grade, localized stage and who received surgery. LEVEL OF EVIDENCE: II -Prognostic Study |
format | Online Article Text |
id | pubmed-6376431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The British Editorial Society of Bone & Joint Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-63764312019-03-05 Chondrosarcoma in a paediatric population: a study of 247 cases Wu, A.-M. Li, G Zheng, J.-W. Chen, C.-H. Chen, D Qiao, Z.-G. Zhao, J.-G. Wang, B Fu, W.-L. Sheng, S.-R. Wu, Y.-S. Tian, N.-F. Lin, Z.-K. Xu, H J Child Orthop Original Clinical Article PURPOSE: The aims of present study are to clarify the follow questions: 1) what constitutes paediatric chondrosarcoma?; 2) what are the effects of the demographic and tumour characteristics on survival in patients with paediatric chondrosarcoma?; 3) which prognostic factors of paediatric chondrosarcoma differ from those of the adult population, which have been reported previously? METHODS: Paediatric patients who were diagnosed with chondrosarcoma were searched for using the case listing session protocol of the National Cancer Institute’s Surveillance, Epidemiology, and End Results 18 databases (1973 to 2014). The extracted demographic information includes: age, race, gender, year of diagnosis, tumour sites, tumour histological subtype, grade, stage and treatment. RESULTS: A total of 247 paediatric chondrosarcoma patients were extracted and included in our present study. We find that the paediatric patients have significantly better survival rates than the adult patients. The year of diagnosis, tumour sites, tumour histological subtype, grade, stage and surgery received are independent prognostic factors for the survival rate of paediatric chondrosarcoma patients, but race, gender and age are not. CONCLUSION: The paediatric chondrosarcoma patients have better survival rates than the adults. Paediatric patients with a diagnosis at an early age, tumour site at the vertebral column and pelvis/sacrococcyx, myxoid variants, high grade, distant stage and who did not have surgery have a poorer prognosis than patients with a diagnosis at a later age, tumour site at limbs, head and base, chondrosarcoma not otherwise specified, lower grade, localized stage and who received surgery. LEVEL OF EVIDENCE: II -Prognostic Study The British Editorial Society of Bone & Joint Surgery 2019-02-01 /pmc/articles/PMC6376431/ /pubmed/30838081 http://dx.doi.org/10.1302/1863-2548.13.180109 Text en Copyright © 2019, The author(s) http://creativecommons.org/licenses/by-nc/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed. |
spellingShingle | Original Clinical Article Wu, A.-M. Li, G Zheng, J.-W. Chen, C.-H. Chen, D Qiao, Z.-G. Zhao, J.-G. Wang, B Fu, W.-L. Sheng, S.-R. Wu, Y.-S. Tian, N.-F. Lin, Z.-K. Xu, H Chondrosarcoma in a paediatric population: a study of 247 cases |
title | Chondrosarcoma in a paediatric population: a study of 247 cases |
title_full | Chondrosarcoma in a paediatric population: a study of 247 cases |
title_fullStr | Chondrosarcoma in a paediatric population: a study of 247 cases |
title_full_unstemmed | Chondrosarcoma in a paediatric population: a study of 247 cases |
title_short | Chondrosarcoma in a paediatric population: a study of 247 cases |
title_sort | chondrosarcoma in a paediatric population: a study of 247 cases |
topic | Original Clinical Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376431/ https://www.ncbi.nlm.nih.gov/pubmed/30838081 http://dx.doi.org/10.1302/1863-2548.13.180109 |
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