Cargando…

Linking migraine frequency with family history of migraine

BACKGROUND: Migraine is a complex genetic disorder that is brought about by multiple genetic and environmental factors. We aimed to assess whether migraine frequency is associated with genetic susceptibility. METHODS: We investigated in 2829 migraine patients (14% males) whether ‘migraine frequency’...

Descripción completa

Detalles Bibliográficos
Autores principales: Pelzer, Nadine, Louter, Mark A, van Zwet, Erik W, Nyholt, Dale R, Ferrari, Michel D, van den Maagdenberg, Arn MJM, Haan, Joost, Terwindt, Gisela M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376592/
https://www.ncbi.nlm.nih.gov/pubmed/29911421
http://dx.doi.org/10.1177/0333102418783295
_version_ 1783395584141426688
author Pelzer, Nadine
Louter, Mark A
van Zwet, Erik W
Nyholt, Dale R
Ferrari, Michel D
van den Maagdenberg, Arn MJM
Haan, Joost
Terwindt, Gisela M
author_facet Pelzer, Nadine
Louter, Mark A
van Zwet, Erik W
Nyholt, Dale R
Ferrari, Michel D
van den Maagdenberg, Arn MJM
Haan, Joost
Terwindt, Gisela M
author_sort Pelzer, Nadine
collection PubMed
description BACKGROUND: Migraine is a complex genetic disorder that is brought about by multiple genetic and environmental factors. We aimed to assess whether migraine frequency is associated with genetic susceptibility. METHODS: We investigated in 2829 migraine patients (14% males) whether ‘migraine frequency’ (measured as the number of migraine days per month) was related to ‘genetic load’ (measured as the number of parents affected with migraine) using a validated web-based questionnaire. In addition, we investigated associations with age-at-onset, migraine subtype, use of acute headache medication, and comorbid depression. RESULTS: We found an association between the number of migraine days per month and family history of migraine for males (p = 0.03), but not for females (p = 0.97). This association was confirmed in a linear regression analysis. Also, a lower age-at-onset (p < 0.001), having migraine with aura (p = 0.03), and a high number of medication days (p = 0.006) were associated with a stronger family history of migraine, whereas lifetime depression (p = 0.13) was not. DISCUSSION: Migraine frequency, as measured by the number of migraine days per month, seems associated with a genetic predisposition only in males. A stronger family history of migraine was also associated with a lower age-at-onset, a higher number of medication days, and migraine with aura. Our findings suggest that specific clinical features of migraine seem more determined by genetic factors.
format Online
Article
Text
id pubmed-6376592
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-63765922019-03-16 Linking migraine frequency with family history of migraine Pelzer, Nadine Louter, Mark A van Zwet, Erik W Nyholt, Dale R Ferrari, Michel D van den Maagdenberg, Arn MJM Haan, Joost Terwindt, Gisela M Cephalalgia Original Articles BACKGROUND: Migraine is a complex genetic disorder that is brought about by multiple genetic and environmental factors. We aimed to assess whether migraine frequency is associated with genetic susceptibility. METHODS: We investigated in 2829 migraine patients (14% males) whether ‘migraine frequency’ (measured as the number of migraine days per month) was related to ‘genetic load’ (measured as the number of parents affected with migraine) using a validated web-based questionnaire. In addition, we investigated associations with age-at-onset, migraine subtype, use of acute headache medication, and comorbid depression. RESULTS: We found an association between the number of migraine days per month and family history of migraine for males (p = 0.03), but not for females (p = 0.97). This association was confirmed in a linear regression analysis. Also, a lower age-at-onset (p < 0.001), having migraine with aura (p = 0.03), and a high number of medication days (p = 0.006) were associated with a stronger family history of migraine, whereas lifetime depression (p = 0.13) was not. DISCUSSION: Migraine frequency, as measured by the number of migraine days per month, seems associated with a genetic predisposition only in males. A stronger family history of migraine was also associated with a lower age-at-onset, a higher number of medication days, and migraine with aura. Our findings suggest that specific clinical features of migraine seem more determined by genetic factors. SAGE Publications 2018-06-17 2019-02 /pmc/articles/PMC6376592/ /pubmed/29911421 http://dx.doi.org/10.1177/0333102418783295 Text en © International Headache Society 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Pelzer, Nadine
Louter, Mark A
van Zwet, Erik W
Nyholt, Dale R
Ferrari, Michel D
van den Maagdenberg, Arn MJM
Haan, Joost
Terwindt, Gisela M
Linking migraine frequency with family history of migraine
title Linking migraine frequency with family history of migraine
title_full Linking migraine frequency with family history of migraine
title_fullStr Linking migraine frequency with family history of migraine
title_full_unstemmed Linking migraine frequency with family history of migraine
title_short Linking migraine frequency with family history of migraine
title_sort linking migraine frequency with family history of migraine
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376592/
https://www.ncbi.nlm.nih.gov/pubmed/29911421
http://dx.doi.org/10.1177/0333102418783295
work_keys_str_mv AT pelzernadine linkingmigrainefrequencywithfamilyhistoryofmigraine
AT loutermarka linkingmigrainefrequencywithfamilyhistoryofmigraine
AT vanzweterikw linkingmigrainefrequencywithfamilyhistoryofmigraine
AT nyholtdaler linkingmigrainefrequencywithfamilyhistoryofmigraine
AT ferrarimicheld linkingmigrainefrequencywithfamilyhistoryofmigraine
AT vandenmaagdenbergarnmjm linkingmigrainefrequencywithfamilyhistoryofmigraine
AT haanjoost linkingmigrainefrequencywithfamilyhistoryofmigraine
AT terwindtgiselam linkingmigrainefrequencywithfamilyhistoryofmigraine