SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments

PP2A is a major regulator of tau phosphorylation, which is principally regulated by an endogenous nuclear protein inhibitor 2 of PP2A (I(2)(PP2A)), also named SET. However, how SET is post-translationally regulated and translocates from the nucleus to the cytoplasm remain incompletely understood. He...

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Detalles Bibliográficos
Autores principales: Qin, Min, Li, Honglian, Bao, Jian, Xia, Yiyuan, Ke, Dan, Wang, Qun, Liu, Rong, Wang, Jian-Zhi, Zhang, Bin, Shu, Xiji, Wang, Xiaochuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376727/
https://www.ncbi.nlm.nih.gov/pubmed/30767764
http://dx.doi.org/10.1186/s40478-019-0663-0

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