ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

BACKGROUND: Angioimmunoblastic T cell lymphoma (AITL) is a distinct subtype of peripheral T cell lymphoma and associated with poor outcomes. The activation status of T cell receptor (TCR) signaling has recently become a focus of attention in terms of the therapeutic targets. However, the molecular p...

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Detalles Bibliográficos
Autores principales: Liu, Yalu, Wang, Xiaogan, Deng, Lijuan, Ping, Lingyan, Shi, Yunfei, Zheng, Wen, Lin, Ningjing, Wang, Xiaopei, Tu, Meifeng, Xie, Yan, Liu, Weiping, Ying, Zhitao, Zhang, Chen, Pan, Zhengying, Wang, Xi, Ding, Ning, Song, Yuqin, Zhu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376795/
https://www.ncbi.nlm.nih.gov/pubmed/30814910
http://dx.doi.org/10.1186/s12935-019-0754-9

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