Seamless Designs: Current Practice and Considerations for Early-Phase Drug Development in Oncology

Traditionally, drug development has evaluated dose, safety, activity, and comparative benefit in a sequence of phases using trial designs and endpoints specifically devised for each phase. Innovations in drug development seek to consolidate the phases and rapidly expand accrual with “seamless” trial...

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Detalles Bibliográficos
Autores principales: Hobbs, Brian P, Barata, Pedro C, Kanjanapan, Yada, Paller, Channing J, Perlmutter, Jane, Pond, Gregory R, Prowell, Tatiana M, Rubin, Eric H, Seymour, Lesley K, Wages, Nolan A, Yap, Timothy A, Feltquate, David, Garrett-Mayer, Elizabeth, Grossman, William, Hong, David S, Ivy, S Percy, Siu, Lillian L, Reeves, Steven A, Rosner, Gary L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376915/
https://www.ncbi.nlm.nih.gov/pubmed/30561713
http://dx.doi.org/10.1093/jnci/djy196

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