Neurophysiological Activations of Predictive and Non-predictive Exogenous Cues: A Cue-Elicited EEG Study on the Generation of Inhibition of Return

In cueing tasks, predictive and non-predictive exogenous spatial cues produce distinct patterns of behavioral effects. Although both cues initially attract attention, only non-predictive cues lead to inhibitory effects (worse performance at the cued location as compared to the uncued location) if the time elapsed between the cue and the target is long enough. However, the process/processes leading to the later inhibitory effect, named inhibition of return (IOR), are still under debate. In the present study, we used cue-elicited EEG activations from predictive and non-predictive exogenous spatial cues to further investigate the neural processes involved in IOR. Unlike previous similar studies, we intermixed both types of cues in a block of trials, in an attempt to identify the unique neurophysiological activations associated with the generation of IOR. We found that predictive and non-predictive cues significantly differed in activation just at 400–470 ms post-cue window. Activation was greater for non-predictive cues in the intraparietal sulcus (IPS), and this activation correlated significantly with IOR effects. These findings support the hypothesis that the posterior parietal cortex plays a crucial role in the generation of IOR.