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Evaluation of agreement between hemoglobin A1c, fasting glucose, and fructosamine in Senegalese individuals with and without sickle-cell trait
Fasting glucose (FG) and glycated hemoglobin A1c (HbA1c) perform sub-optimally in people of African origin, especially in individuals with sickle-cell trait (SCT). The purpose of this study was to compare the relationships between HbA1c, FG, and fructosamine in individuals from Senegal with and with...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377192/ https://www.ncbi.nlm.nih.gov/pubmed/30768636 http://dx.doi.org/10.1371/journal.pone.0212552 |
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author | Skinner, Sarah Diaw, Mor Ndour Mbaye, Maïmouna Joly, Philippe Renoux, Céline Masson, Céline Cuerq, Charlotte Lopez, Philomène Ndour, Malick Diedhiou, Demba Sow, Djiby Diop, Saliou Samb, Abdoulaye Pialoux, Vincent Connes, Philippe |
author_facet | Skinner, Sarah Diaw, Mor Ndour Mbaye, Maïmouna Joly, Philippe Renoux, Céline Masson, Céline Cuerq, Charlotte Lopez, Philomène Ndour, Malick Diedhiou, Demba Sow, Djiby Diop, Saliou Samb, Abdoulaye Pialoux, Vincent Connes, Philippe |
author_sort | Skinner, Sarah |
collection | PubMed |
description | Fasting glucose (FG) and glycated hemoglobin A1c (HbA1c) perform sub-optimally in people of African origin, especially in individuals with sickle-cell trait (SCT). The purpose of this study was to compare the relationships between HbA1c, FG, and fructosamine in individuals from Senegal with and without SCT. HbA1c, FG, and fructosamine were measured in 203 adults from Senegal (100 control: 45 with type 2 diabetes (T2D); 103 SCT: 51 with T2D). Significant, positive correlations were observed between HbA1c and FG, fructosamine and FG, and fructosamine and HbA1c in both groups. The limits of agreement were inappropriately large in both groups for the Bland-Altman plots of HbA1c and FG (control: -95.97 to 83.97%; SCT: -115.9 to 91.52%), fructosamine and FG (control: -100.6 to 99.89%; SCT: -105.6 to 100.6%), and fructosamine and HbA1c (control: -52.03 to 38.98%; SCT: -88.04 to 71.41%). In both groups, the greatest proportion of subjects were considered above the clinical cut-point for hyperglycemia when fructosamine was used as the criterion (control: 33%; SCT: 44.6%), and the lowest percentage of subjects were classified as over the clinical cut-point when HbA1c was used as the criterion (control: 21%; SCT: 27.7%).Substantial disparities between HbA1c, FG, and fructosamine were observed in both groups, and these differences were exaggerated in the SCT group. Therefore, these three biomarkers should not be considered to be interchangeable measures of glycemic control. These biomarkers should be used thoughtfully, and special care should be taken when using them in individuals with SCT. |
format | Online Article Text |
id | pubmed-6377192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63771922019-03-01 Evaluation of agreement between hemoglobin A1c, fasting glucose, and fructosamine in Senegalese individuals with and without sickle-cell trait Skinner, Sarah Diaw, Mor Ndour Mbaye, Maïmouna Joly, Philippe Renoux, Céline Masson, Céline Cuerq, Charlotte Lopez, Philomène Ndour, Malick Diedhiou, Demba Sow, Djiby Diop, Saliou Samb, Abdoulaye Pialoux, Vincent Connes, Philippe PLoS One Research Article Fasting glucose (FG) and glycated hemoglobin A1c (HbA1c) perform sub-optimally in people of African origin, especially in individuals with sickle-cell trait (SCT). The purpose of this study was to compare the relationships between HbA1c, FG, and fructosamine in individuals from Senegal with and without SCT. HbA1c, FG, and fructosamine were measured in 203 adults from Senegal (100 control: 45 with type 2 diabetes (T2D); 103 SCT: 51 with T2D). Significant, positive correlations were observed between HbA1c and FG, fructosamine and FG, and fructosamine and HbA1c in both groups. The limits of agreement were inappropriately large in both groups for the Bland-Altman plots of HbA1c and FG (control: -95.97 to 83.97%; SCT: -115.9 to 91.52%), fructosamine and FG (control: -100.6 to 99.89%; SCT: -105.6 to 100.6%), and fructosamine and HbA1c (control: -52.03 to 38.98%; SCT: -88.04 to 71.41%). In both groups, the greatest proportion of subjects were considered above the clinical cut-point for hyperglycemia when fructosamine was used as the criterion (control: 33%; SCT: 44.6%), and the lowest percentage of subjects were classified as over the clinical cut-point when HbA1c was used as the criterion (control: 21%; SCT: 27.7%).Substantial disparities between HbA1c, FG, and fructosamine were observed in both groups, and these differences were exaggerated in the SCT group. Therefore, these three biomarkers should not be considered to be interchangeable measures of glycemic control. These biomarkers should be used thoughtfully, and special care should be taken when using them in individuals with SCT. Public Library of Science 2019-02-15 /pmc/articles/PMC6377192/ /pubmed/30768636 http://dx.doi.org/10.1371/journal.pone.0212552 Text en © 2019 Skinner et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Skinner, Sarah Diaw, Mor Ndour Mbaye, Maïmouna Joly, Philippe Renoux, Céline Masson, Céline Cuerq, Charlotte Lopez, Philomène Ndour, Malick Diedhiou, Demba Sow, Djiby Diop, Saliou Samb, Abdoulaye Pialoux, Vincent Connes, Philippe Evaluation of agreement between hemoglobin A1c, fasting glucose, and fructosamine in Senegalese individuals with and without sickle-cell trait |
title | Evaluation of agreement between hemoglobin A1c, fasting glucose, and fructosamine in Senegalese individuals with and without sickle-cell trait |
title_full | Evaluation of agreement between hemoglobin A1c, fasting glucose, and fructosamine in Senegalese individuals with and without sickle-cell trait |
title_fullStr | Evaluation of agreement between hemoglobin A1c, fasting glucose, and fructosamine in Senegalese individuals with and without sickle-cell trait |
title_full_unstemmed | Evaluation of agreement between hemoglobin A1c, fasting glucose, and fructosamine in Senegalese individuals with and without sickle-cell trait |
title_short | Evaluation of agreement between hemoglobin A1c, fasting glucose, and fructosamine in Senegalese individuals with and without sickle-cell trait |
title_sort | evaluation of agreement between hemoglobin a1c, fasting glucose, and fructosamine in senegalese individuals with and without sickle-cell trait |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377192/ https://www.ncbi.nlm.nih.gov/pubmed/30768636 http://dx.doi.org/10.1371/journal.pone.0212552 |
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