Corneal ulceration associated with Nivolumab use

PURPOSE: To describe a case of corneal ulceration associated with Nivolumab use. OBSERVATIONS: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies – including surgery to cover the ulcer with a conjunc...

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Detalles Bibliográficos
Autores principales: Parker, Jack S., Feagin, Wyatt, Wang, Christopher, Heersink, Marius, Parker, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377387/
https://www.ncbi.nlm.nih.gov/pubmed/30815619
http://dx.doi.org/10.1016/j.ajoc.2019.01.013
Descripción
Sumario:PURPOSE: To describe a case of corneal ulceration associated with Nivolumab use. OBSERVATIONS: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies – including surgery to cover the ulcer with a conjunctival flap – until topical prednisolone acetate was tried, which was curative. CONCLUSIONS AND IMPORTANCE: Nivolumab use may be associated with a form of steroid-responsive corneal ulceration.

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