Corneal ulceration associated with Nivolumab use

PURPOSE: To describe a case of corneal ulceration associated with Nivolumab use. OBSERVATIONS: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies – including surgery to cover the ulcer with a conjunc...

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Detalles Bibliográficos
Autores principales: Parker, Jack S., Feagin, Wyatt, Wang, Christopher, Heersink, Marius, Parker, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377387/
https://www.ncbi.nlm.nih.gov/pubmed/30815619
http://dx.doi.org/10.1016/j.ajoc.2019.01.013
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author Parker, Jack S.
Feagin, Wyatt
Wang, Christopher
Heersink, Marius
Parker, John S.
author_facet Parker, Jack S.
Feagin, Wyatt
Wang, Christopher
Heersink, Marius
Parker, John S.
author_sort Parker, Jack S.
collection PubMed
description PURPOSE: To describe a case of corneal ulceration associated with Nivolumab use. OBSERVATIONS: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies – including surgery to cover the ulcer with a conjunctival flap – until topical prednisolone acetate was tried, which was curative. CONCLUSIONS AND IMPORTANCE: Nivolumab use may be associated with a form of steroid-responsive corneal ulceration.
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spelling pubmed-63773872019-02-27 Corneal ulceration associated with Nivolumab use Parker, Jack S. Feagin, Wyatt Wang, Christopher Heersink, Marius Parker, John S. Am J Ophthalmol Case Rep Case Report PURPOSE: To describe a case of corneal ulceration associated with Nivolumab use. OBSERVATIONS: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies – including surgery to cover the ulcer with a conjunctival flap – until topical prednisolone acetate was tried, which was curative. CONCLUSIONS AND IMPORTANCE: Nivolumab use may be associated with a form of steroid-responsive corneal ulceration. Elsevier 2019-02-07 /pmc/articles/PMC6377387/ /pubmed/30815619 http://dx.doi.org/10.1016/j.ajoc.2019.01.013 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Parker, Jack S.
Feagin, Wyatt
Wang, Christopher
Heersink, Marius
Parker, John S.
Corneal ulceration associated with Nivolumab use
title Corneal ulceration associated with Nivolumab use
title_full Corneal ulceration associated with Nivolumab use
title_fullStr Corneal ulceration associated with Nivolumab use
title_full_unstemmed Corneal ulceration associated with Nivolumab use
title_short Corneal ulceration associated with Nivolumab use
title_sort corneal ulceration associated with nivolumab use
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377387/
https://www.ncbi.nlm.nih.gov/pubmed/30815619
http://dx.doi.org/10.1016/j.ajoc.2019.01.013
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AT wangchristopher cornealulcerationassociatedwithnivolumabuse
AT heersinkmarius cornealulcerationassociatedwithnivolumabuse
AT parkerjohns cornealulcerationassociatedwithnivolumabuse

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