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Desquamative interstitial pneumonia with clinical, radiological and histologic correlation
Respiratory bronchiolitis-associated interstitial lung disease (ILD), desquamative interstitial pneumonia (DIP), and pulmonary Langerhans cell histiocytosis are entities of smoking-related ILD. While clinically regarded as 2 separate forms of idiopathic interstitial pneumonia, DIP, and respiratory b...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377394/ https://www.ncbi.nlm.nih.gov/pubmed/30815049 http://dx.doi.org/10.1016/j.radcr.2019.01.016 |
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author | Medenica, Miras Medenica, Milic |
author_facet | Medenica, Miras Medenica, Milic |
author_sort | Medenica, Miras |
collection | PubMed |
description | Respiratory bronchiolitis-associated interstitial lung disease (ILD), desquamative interstitial pneumonia (DIP), and pulmonary Langerhans cell histiocytosis are entities of smoking-related ILD. While clinically regarded as 2 separate forms of idiopathic interstitial pneumonia, DIP, and respiratory bronchiolitis-associated ILD are thought to be representing ends of a continuous spectrum of disease that primarily affects tobacco smokers. This case report presents a 53-year-old female patient who has 58 pack-year smoking history who has been experiencing a dry cough and epigastric pains for 2 years. Open-lung biopsy is performed and histopathology indicated smoking-related interstitial fibrosis. The patient did not stop smoking, which after a year leads to significant clinical deterioration with a notable decrease in diffusion for carbon monoxide capacity. Upon smoking cessation and treatment with corticosteroids, a significant clinical improvement is achieved. In smokers complaining of cough and reduced exercise tolerance and in whom evidence of interstitial fibrosis is demonstrated radiologically, DIP should be considered as a differential diagnosis. Smoking is the exclusive etiologic factor of pathogenesis of DIP. |
format | Online Article Text |
id | pubmed-6377394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-63773942019-02-27 Desquamative interstitial pneumonia with clinical, radiological and histologic correlation Medenica, Miras Medenica, Milic Radiol Case Rep Chest Respiratory bronchiolitis-associated interstitial lung disease (ILD), desquamative interstitial pneumonia (DIP), and pulmonary Langerhans cell histiocytosis are entities of smoking-related ILD. While clinically regarded as 2 separate forms of idiopathic interstitial pneumonia, DIP, and respiratory bronchiolitis-associated ILD are thought to be representing ends of a continuous spectrum of disease that primarily affects tobacco smokers. This case report presents a 53-year-old female patient who has 58 pack-year smoking history who has been experiencing a dry cough and epigastric pains for 2 years. Open-lung biopsy is performed and histopathology indicated smoking-related interstitial fibrosis. The patient did not stop smoking, which after a year leads to significant clinical deterioration with a notable decrease in diffusion for carbon monoxide capacity. Upon smoking cessation and treatment with corticosteroids, a significant clinical improvement is achieved. In smokers complaining of cough and reduced exercise tolerance and in whom evidence of interstitial fibrosis is demonstrated radiologically, DIP should be considered as a differential diagnosis. Smoking is the exclusive etiologic factor of pathogenesis of DIP. Elsevier 2019-02-13 /pmc/articles/PMC6377394/ /pubmed/30815049 http://dx.doi.org/10.1016/j.radcr.2019.01.016 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Chest Medenica, Miras Medenica, Milic Desquamative interstitial pneumonia with clinical, radiological and histologic correlation |
title | Desquamative interstitial pneumonia with clinical, radiological and histologic correlation |
title_full | Desquamative interstitial pneumonia with clinical, radiological and histologic correlation |
title_fullStr | Desquamative interstitial pneumonia with clinical, radiological and histologic correlation |
title_full_unstemmed | Desquamative interstitial pneumonia with clinical, radiological and histologic correlation |
title_short | Desquamative interstitial pneumonia with clinical, radiological and histologic correlation |
title_sort | desquamative interstitial pneumonia with clinical, radiological and histologic correlation |
topic | Chest |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377394/ https://www.ncbi.nlm.nih.gov/pubmed/30815049 http://dx.doi.org/10.1016/j.radcr.2019.01.016 |
work_keys_str_mv | AT medenicamiras desquamativeinterstitialpneumoniawithclinicalradiologicalandhistologiccorrelation AT medenicamilic desquamativeinterstitialpneumoniawithclinicalradiologicalandhistologiccorrelation |