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The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases
PURPOSE: Thyroidectomy is the preferred approach as the definitive treatment for Graves’ disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study. METHODS: The study concerned a retrospective review of 594...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377402/ https://www.ncbi.nlm.nih.gov/pubmed/30815364 http://dx.doi.org/10.1016/j.jcte.2019.100183 |
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author | Cipolla, Calogero Graceffa, Giuseppa Calamia, Sergio Fiorentino, Eugenio Pantuso, Gianni Vieni, Salvatore Latteri, Mario |
author_facet | Cipolla, Calogero Graceffa, Giuseppa Calamia, Sergio Fiorentino, Eugenio Pantuso, Gianni Vieni, Salvatore Latteri, Mario |
author_sort | Cipolla, Calogero |
collection | PubMed |
description | PURPOSE: Thyroidectomy is the preferred approach as the definitive treatment for Graves’ disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study. METHODS: The study concerned a retrospective review of 594 patients, undergoing a total thyroidectomy for Graves’ disease. The incidence of complications and outcomes on hyperthyroidism and correlated symptoms resolution were also evaluated. RESULTS: The mean age of the patients was of 44.7 ± 12.7 years and 456 patients (76.7%) were females. The mean gland weight was 67.3 ± 10.8 g (range: 20–350 g) and, in 397 patients (66.8%), the gland weighed >40 g. The mean operative time was 125 ± 23.1 min (range: 65–212 min). Temporary and permanent hypocalcaemia developed in 241 (40.6%) and 3 patients (0.5%), respectively. Temporary and permanent recurrent laryngeal nerve palsy were recorded in 31 (5.2%) and 1 patients (0.16%) respectively. No patient developed a thyroid storm. On multivariate analysis, patient age ≤50 years (Odds ratio: 1; 95% Confidence Interval: 0.843–0.901) and thyroid weight >40 g (Odds ratio: 1; 95%, Confidence Interval: 0.852–0.974), were mainly associated with the occurrence of complications. CONCLUSION: This high-volume surgeon experience demonstrates that total thyroidectomy is a safe and effective treatment for Graves’ disease. It is associated with a very low incidence rate of post-operative complications, most of which are transitory; therefore, it offers a rapid and definitive control of hyperthyroidism and its related symptoms. |
format | Online Article Text |
id | pubmed-6377402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-63774022019-02-27 The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases Cipolla, Calogero Graceffa, Giuseppa Calamia, Sergio Fiorentino, Eugenio Pantuso, Gianni Vieni, Salvatore Latteri, Mario J Clin Transl Endocrinol Research Paper PURPOSE: Thyroidectomy is the preferred approach as the definitive treatment for Graves’ disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study. METHODS: The study concerned a retrospective review of 594 patients, undergoing a total thyroidectomy for Graves’ disease. The incidence of complications and outcomes on hyperthyroidism and correlated symptoms resolution were also evaluated. RESULTS: The mean age of the patients was of 44.7 ± 12.7 years and 456 patients (76.7%) were females. The mean gland weight was 67.3 ± 10.8 g (range: 20–350 g) and, in 397 patients (66.8%), the gland weighed >40 g. The mean operative time was 125 ± 23.1 min (range: 65–212 min). Temporary and permanent hypocalcaemia developed in 241 (40.6%) and 3 patients (0.5%), respectively. Temporary and permanent recurrent laryngeal nerve palsy were recorded in 31 (5.2%) and 1 patients (0.16%) respectively. No patient developed a thyroid storm. On multivariate analysis, patient age ≤50 years (Odds ratio: 1; 95% Confidence Interval: 0.843–0.901) and thyroid weight >40 g (Odds ratio: 1; 95%, Confidence Interval: 0.852–0.974), were mainly associated with the occurrence of complications. CONCLUSION: This high-volume surgeon experience demonstrates that total thyroidectomy is a safe and effective treatment for Graves’ disease. It is associated with a very low incidence rate of post-operative complications, most of which are transitory; therefore, it offers a rapid and definitive control of hyperthyroidism and its related symptoms. Elsevier 2019-02-07 /pmc/articles/PMC6377402/ /pubmed/30815364 http://dx.doi.org/10.1016/j.jcte.2019.100183 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Cipolla, Calogero Graceffa, Giuseppa Calamia, Sergio Fiorentino, Eugenio Pantuso, Gianni Vieni, Salvatore Latteri, Mario The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
title | The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
title_full | The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
title_fullStr | The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
title_full_unstemmed | The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
title_short | The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
title_sort | value of total thyroidectomy as the definitive treatment for graves’ disease: a single centre experience of 594 cases |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377402/ https://www.ncbi.nlm.nih.gov/pubmed/30815364 http://dx.doi.org/10.1016/j.jcte.2019.100183 |
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