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The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases

PURPOSE: Thyroidectomy is the preferred approach as the definitive treatment for Graves’ disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study. METHODS: The study concerned a retrospective review of 594...

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Autores principales: Cipolla, Calogero, Graceffa, Giuseppa, Calamia, Sergio, Fiorentino, Eugenio, Pantuso, Gianni, Vieni, Salvatore, Latteri, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377402/
https://www.ncbi.nlm.nih.gov/pubmed/30815364
http://dx.doi.org/10.1016/j.jcte.2019.100183
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author Cipolla, Calogero
Graceffa, Giuseppa
Calamia, Sergio
Fiorentino, Eugenio
Pantuso, Gianni
Vieni, Salvatore
Latteri, Mario
author_facet Cipolla, Calogero
Graceffa, Giuseppa
Calamia, Sergio
Fiorentino, Eugenio
Pantuso, Gianni
Vieni, Salvatore
Latteri, Mario
author_sort Cipolla, Calogero
collection PubMed
description PURPOSE: Thyroidectomy is the preferred approach as the definitive treatment for Graves’ disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study. METHODS: The study concerned a retrospective review of 594 patients, undergoing a total thyroidectomy for Graves’ disease. The incidence of complications and outcomes on hyperthyroidism and correlated symptoms resolution were also evaluated. RESULTS: The mean age of the patients was of 44.7 ± 12.7 years and 456 patients (76.7%) were females. The mean gland weight was 67.3 ± 10.8 g (range: 20–350 g) and, in 397 patients (66.8%), the gland weighed >40 g. The mean operative time was 125 ± 23.1 min (range: 65–212 min). Temporary and permanent hypocalcaemia developed in 241 (40.6%) and 3 patients (0.5%), respectively. Temporary and permanent recurrent laryngeal nerve palsy were recorded in 31 (5.2%) and 1 patients (0.16%) respectively. No patient developed a thyroid storm. On multivariate analysis, patient age ≤50 years (Odds ratio: 1; 95% Confidence Interval: 0.843–0.901) and thyroid weight >40 g (Odds ratio: 1; 95%, Confidence Interval: 0.852–0.974), were mainly associated with the occurrence of complications. CONCLUSION: This high-volume surgeon experience demonstrates that total thyroidectomy is a safe and effective treatment for Graves’ disease. It is associated with a very low incidence rate of post-operative complications, most of which are transitory; therefore, it offers a rapid and definitive control of hyperthyroidism and its related symptoms.
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spelling pubmed-63774022019-02-27 The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases Cipolla, Calogero Graceffa, Giuseppa Calamia, Sergio Fiorentino, Eugenio Pantuso, Gianni Vieni, Salvatore Latteri, Mario J Clin Transl Endocrinol Research Paper PURPOSE: Thyroidectomy is the preferred approach as the definitive treatment for Graves’ disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study. METHODS: The study concerned a retrospective review of 594 patients, undergoing a total thyroidectomy for Graves’ disease. The incidence of complications and outcomes on hyperthyroidism and correlated symptoms resolution were also evaluated. RESULTS: The mean age of the patients was of 44.7 ± 12.7 years and 456 patients (76.7%) were females. The mean gland weight was 67.3 ± 10.8 g (range: 20–350 g) and, in 397 patients (66.8%), the gland weighed >40 g. The mean operative time was 125 ± 23.1 min (range: 65–212 min). Temporary and permanent hypocalcaemia developed in 241 (40.6%) and 3 patients (0.5%), respectively. Temporary and permanent recurrent laryngeal nerve palsy were recorded in 31 (5.2%) and 1 patients (0.16%) respectively. No patient developed a thyroid storm. On multivariate analysis, patient age ≤50 years (Odds ratio: 1; 95% Confidence Interval: 0.843–0.901) and thyroid weight >40 g (Odds ratio: 1; 95%, Confidence Interval: 0.852–0.974), were mainly associated with the occurrence of complications. CONCLUSION: This high-volume surgeon experience demonstrates that total thyroidectomy is a safe and effective treatment for Graves’ disease. It is associated with a very low incidence rate of post-operative complications, most of which are transitory; therefore, it offers a rapid and definitive control of hyperthyroidism and its related symptoms. Elsevier 2019-02-07 /pmc/articles/PMC6377402/ /pubmed/30815364 http://dx.doi.org/10.1016/j.jcte.2019.100183 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Cipolla, Calogero
Graceffa, Giuseppa
Calamia, Sergio
Fiorentino, Eugenio
Pantuso, Gianni
Vieni, Salvatore
Latteri, Mario
The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases
title The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases
title_full The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases
title_fullStr The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases
title_full_unstemmed The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases
title_short The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases
title_sort value of total thyroidectomy as the definitive treatment for graves’ disease: a single centre experience of 594 cases
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377402/
https://www.ncbi.nlm.nih.gov/pubmed/30815364
http://dx.doi.org/10.1016/j.jcte.2019.100183
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