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Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA)
This study examines longitudinal changes in the concreteness of nouns produced by human patients with semantic variant primary progressive aphasia (svPPA). Cross-sectional studies show that patients with svPPA demonstrate severe loss of concrete noun knowledge linked to atrophy of the left ventral t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Society for Neuroscience
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377408/ https://www.ncbi.nlm.nih.gov/pubmed/30783611 http://dx.doi.org/10.1523/ENEURO.0197-18.2018 |
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author | Cousins, Katheryn A. Q. Ash, Sharon Olm, Christopher A. Grossman, Murray |
author_facet | Cousins, Katheryn A. Q. Ash, Sharon Olm, Christopher A. Grossman, Murray |
author_sort | Cousins, Katheryn A. Q. |
collection | PubMed |
description | This study examines longitudinal changes in the concreteness of nouns produced by human patients with semantic variant primary progressive aphasia (svPPA). Cross-sectional studies show that patients with svPPA demonstrate severe loss of concrete noun knowledge linked to atrophy of the left ventral temporal lobe. It is unknown how disease spread and duration affect the magnitude of the concreteness impairment in svPPA. We evaluate longitudinal spoken production of concrete nouns in svPPA, and relate this to changes in longitudinal MRI measures of gray matter (GM). Noun concreteness in svPPA is compared to that of behavioral variant frontotemporal dementia (bvFTD) patients, who typically demonstrate highly concrete speech. We elicited naturalistic speech samples at two time points (time 1 and time 2) in patients with svPPA (n = 11) and bvFTD (n = 15) through descriptions of the Cookie Theft picture and evaluated each spoken noun for concreteness. Compared to bvFTD patients whose noun production remained highly concrete throughout the testing period, mixed-effects models revealed that noun concreteness significantly decreased as disease progressed in svPPA. We also measured longitudinal changes to GM in a subset of svPPA patients (n = 7), who showed significant decline in the left and right temporal and frontal regions. Regression analyses revealed that longitudinal GM atrophy in the right fusiform and parahippocampal gyri and the left superior temporal gyrus was related to decreasing noun concreteness. These results suggest that progressive atrophy of the ventral temporal lobe in svPPA contributes to declining concrete noun production over time. |
format | Online Article Text |
id | pubmed-6377408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-63774082019-02-19 Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA) Cousins, Katheryn A. Q. Ash, Sharon Olm, Christopher A. Grossman, Murray eNeuro New Research This study examines longitudinal changes in the concreteness of nouns produced by human patients with semantic variant primary progressive aphasia (svPPA). Cross-sectional studies show that patients with svPPA demonstrate severe loss of concrete noun knowledge linked to atrophy of the left ventral temporal lobe. It is unknown how disease spread and duration affect the magnitude of the concreteness impairment in svPPA. We evaluate longitudinal spoken production of concrete nouns in svPPA, and relate this to changes in longitudinal MRI measures of gray matter (GM). Noun concreteness in svPPA is compared to that of behavioral variant frontotemporal dementia (bvFTD) patients, who typically demonstrate highly concrete speech. We elicited naturalistic speech samples at two time points (time 1 and time 2) in patients with svPPA (n = 11) and bvFTD (n = 15) through descriptions of the Cookie Theft picture and evaluated each spoken noun for concreteness. Compared to bvFTD patients whose noun production remained highly concrete throughout the testing period, mixed-effects models revealed that noun concreteness significantly decreased as disease progressed in svPPA. We also measured longitudinal changes to GM in a subset of svPPA patients (n = 7), who showed significant decline in the left and right temporal and frontal regions. Regression analyses revealed that longitudinal GM atrophy in the right fusiform and parahippocampal gyri and the left superior temporal gyrus was related to decreasing noun concreteness. These results suggest that progressive atrophy of the ventral temporal lobe in svPPA contributes to declining concrete noun production over time. Society for Neuroscience 2018-01-10 /pmc/articles/PMC6377408/ /pubmed/30783611 http://dx.doi.org/10.1523/ENEURO.0197-18.2018 Text en Copyright © 2018 Cousins et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | New Research Cousins, Katheryn A. Q. Ash, Sharon Olm, Christopher A. Grossman, Murray Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA) |
title | Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA) |
title_full | Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA) |
title_fullStr | Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA) |
title_full_unstemmed | Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA) |
title_short | Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA) |
title_sort | longitudinal changes in semantic concreteness in semantic variant primary progressive aphasia (svppa) |
topic | New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377408/ https://www.ncbi.nlm.nih.gov/pubmed/30783611 http://dx.doi.org/10.1523/ENEURO.0197-18.2018 |
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