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The effects of 2-hydroxyglutarate on the tumorigenesis of gliomas

Mutation of the isocitrate-dehydrogenase (IDH) enzymes is one of the central research topics regarding gliomagenesis. Indeed, 70% of gliomas are associated with a gain-of-function IDH mutation and consequently synthesize the oncometabolite, 2-hydroxyglutarate (2-HG). This review aims to elucidate th...

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Detalles Bibliográficos
Autores principales:	Reiter-Brennan, Cara, Semmler, Lukas, Klein, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Termedia Publishing House 2018
Materias:	Review Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377424/ https://www.ncbi.nlm.nih.gov/pubmed/30783384 http://dx.doi.org/10.5114/wo.2018.82642

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