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Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence

The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging. This theory has been limited, however, by an inability to identify and isolate individual senescent cells within an intact organism. T...

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Detalles Bibliográficos
Autores principales:	Liu, Jie-Yu, Souroullas, George P., Diekman, Brian O., Krishnamurthy, Janakiraman, Hall, Brandon M., Sorrentino, Jessica A., Parker, Joel S., Sessions, Garrett A., Gudkov, Andrei V., Sharpless, Norman E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377452/ https://www.ncbi.nlm.nih.gov/pubmed/30683717 http://dx.doi.org/10.1073/pnas.1818313116

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