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Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study
OBJECTIVE: To develop a predictive model for fetal loss in women with systemic lupus erythematosus (SLE). DESIGN: A retrospective cohort study. SETTING: Data were collected in a tertiary medical centre, located in Shanghai, China, from September 2011 to May 2017. PARTICIPANTS: 338 pregnancies with S...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377554/ https://www.ncbi.nlm.nih.gov/pubmed/30755448 http://dx.doi.org/10.1136/bmjopen-2018-023849 |
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author | Wu, Jiayue Zhang, Wei-Hong Ma, Jinghang Bao, Chunde Liu, Jinlin Di, Wen |
author_facet | Wu, Jiayue Zhang, Wei-Hong Ma, Jinghang Bao, Chunde Liu, Jinlin Di, Wen |
author_sort | Wu, Jiayue |
collection | PubMed |
description | OBJECTIVE: To develop a predictive model for fetal loss in women with systemic lupus erythematosus (SLE). DESIGN: A retrospective cohort study. SETTING: Data were collected in a tertiary medical centre, located in Shanghai, China, from September 2011 to May 2017. PARTICIPANTS: 338 pregnancies with SLE were analysed retrospectively. Cases of multiple pregnancy and those in which artificial abortion was performed for personal reasons were excluded. PRIMARY OUTCOME MEASURES: Fetal loss was the primary outcome. A stepwise regression to identify the predictors related to the fetal loss and coefficient B of each variable was used to develop a predictive model and make a corresponding risk classification. The Hosmer-Lemeshow test, Omnibus test and area under the receiver-operating characteristic curve (AUC) were used to assess the goodness-of-fit and discrimination of the predictive model. A 10-fold cross validation was used to assess the model for overfitting. RESULTS: Unplanned pregnancies (OR 2.84, 95% CI 1.12 to 7.22), C(3) hypocomplementemia (OR 5.46, 95% CI 2.30 to 12.97) and 24 hour-urinary protein level (0.3≤protein<1.0 g/24 hours: OR 2.10, 95% CI 0.63 to 6.95; protein≥1.0 g/24 hours: OR 5.89, 95% CI 2.30 to 15.06) were selected by the stepwise regression. The Hosmer-Lemeshow test resulted in p=0.325; the Omnibus test resulted in p<0.001 and the AUC was 0.829 (95% CI 0.744 to 0.91) in the regression model. The corresponding risk score classification was divided into low risk (0–3) and high risk groups (>3), with a sensitivity of 60.5%, a specificity of 93.3%, positive likelihood ratio of 9.03 and negative likelihood ratio of 0.42. CONCLUSIONS: A predictive model for fetal loss in women with SLE was developed using the timing of conception, C(3) complement and 24 hour-urinary protein level. This model may help clinicians in identifying women with high risk pregnancies, thereby carrying out monitoring or/and interventions for improving fetal outcomes. |
format | Online Article Text |
id | pubmed-6377554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-63775542019-03-05 Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study Wu, Jiayue Zhang, Wei-Hong Ma, Jinghang Bao, Chunde Liu, Jinlin Di, Wen BMJ Open Obstetrics and Gynaecology OBJECTIVE: To develop a predictive model for fetal loss in women with systemic lupus erythematosus (SLE). DESIGN: A retrospective cohort study. SETTING: Data were collected in a tertiary medical centre, located in Shanghai, China, from September 2011 to May 2017. PARTICIPANTS: 338 pregnancies with SLE were analysed retrospectively. Cases of multiple pregnancy and those in which artificial abortion was performed for personal reasons were excluded. PRIMARY OUTCOME MEASURES: Fetal loss was the primary outcome. A stepwise regression to identify the predictors related to the fetal loss and coefficient B of each variable was used to develop a predictive model and make a corresponding risk classification. The Hosmer-Lemeshow test, Omnibus test and area under the receiver-operating characteristic curve (AUC) were used to assess the goodness-of-fit and discrimination of the predictive model. A 10-fold cross validation was used to assess the model for overfitting. RESULTS: Unplanned pregnancies (OR 2.84, 95% CI 1.12 to 7.22), C(3) hypocomplementemia (OR 5.46, 95% CI 2.30 to 12.97) and 24 hour-urinary protein level (0.3≤protein<1.0 g/24 hours: OR 2.10, 95% CI 0.63 to 6.95; protein≥1.0 g/24 hours: OR 5.89, 95% CI 2.30 to 15.06) were selected by the stepwise regression. The Hosmer-Lemeshow test resulted in p=0.325; the Omnibus test resulted in p<0.001 and the AUC was 0.829 (95% CI 0.744 to 0.91) in the regression model. The corresponding risk score classification was divided into low risk (0–3) and high risk groups (>3), with a sensitivity of 60.5%, a specificity of 93.3%, positive likelihood ratio of 9.03 and negative likelihood ratio of 0.42. CONCLUSIONS: A predictive model for fetal loss in women with SLE was developed using the timing of conception, C(3) complement and 24 hour-urinary protein level. This model may help clinicians in identifying women with high risk pregnancies, thereby carrying out monitoring or/and interventions for improving fetal outcomes. BMJ Publishing Group 2019-02-11 /pmc/articles/PMC6377554/ /pubmed/30755448 http://dx.doi.org/10.1136/bmjopen-2018-023849 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Obstetrics and Gynaecology Wu, Jiayue Zhang, Wei-Hong Ma, Jinghang Bao, Chunde Liu, Jinlin Di, Wen Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study |
title | Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study |
title_full | Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study |
title_fullStr | Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study |
title_full_unstemmed | Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study |
title_short | Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study |
title_sort | prediction of fetal loss in chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study |
topic | Obstetrics and Gynaecology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377554/ https://www.ncbi.nlm.nih.gov/pubmed/30755448 http://dx.doi.org/10.1136/bmjopen-2018-023849 |
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